Adv Pharm Bull. 2014;4(5):449-454.
doi: 10.5681/apb.2014.066
PMID: 25364661
PMCID: PMC4213784
  Abstract View: 557
  PDF Download: 221

Original Research

Effects of L- Arginine Supplementation on Antioxidant Status and Body Composition in Obese Patients with Pre-diabetes: A Randomized Controlled Clinical Trial

Siavash Fazelian 1, Mostafa Hoseini 2, Nazli Namazi 3, Javad Heshmati 1, Mehdi Sepidar Kish 2, Maryam Mirfatahi 4, Ahmad Saedi Some Olia 1 *

1 Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
2 Department of Biostatistics, Faculty of Health, Tehran University of Medical Sciences, Tehran, Iran.
3 Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Faculty of Food and Nutrition, Shahid Beheshti University of Medical Sciences, Tehran, Iran.


Purpose: The aim of present study was to determine effects of L-Arginine supplementation on antioxidant status and body composition in obese patients with prediabetes.
Methods: A double-blind randomized control trial was performed on 46 (24 men, 22 women) obese patients with prediabetes. They were divided randomly into two groups. Patients in intervention (n = 23) and control group (n=23) received 3 gr/day L-arginine and placebo, respectively for 8 weeks. Anthropometric indices, dietary intake and biochemical measurements ((serum total antioxidant capacity (TAC), Glutathione Peroxidase (GPx) and Superoxide Dismutase (SOD)) were performed at the baseline and after 8-week intervention.
Results: The mean age and BMI of participants were 44.29±8.65 years old and 28.14±1.35 kg/m2, respectively. At the end of study, in both intervention and control group, percentage of carbohydrate decreased and %fat intake increased compared to the baseline (P<0.05). After adjusting for dietary intake, no significant difference was observed in Fat Mass (FM) and Fat Free Mass (FFM) between two groups (P>0.05). Among measured biochemical factors, only serum TAC level showed significant differences at the end of study in the intervention group compared to the control group (pv<0.01).
Conclusion: 3gr/day L-Arginine supplementation increased TAC level in obese patients with prediabetes.
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