Adv Pharm Bull. 2015;5(4):507-514.
doi: 10.15171/apb.2015.069
PMID: 26819923
PMCID: PMC4729356
Scopus id: 84949661490
  Abstract View: 520
  PDF Download: 218

Original Research

A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

Akbar Aliasgharzadeh 1, Mohammad Khalili 2, Elham Mirtaheri 3, Bahram Pourghassem Gargari 3, Farnaz Tavakoli 1, Mahdieh Abbasalizad Farhangi 4, Hossein Babaei 5, Parvin Dehghan 6 *

1 Faculty of Medicine, Bone Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Neurosciences Research Center Tabriz University of Medical Sciences, Tabriz, Iran.
3 Department of Biochemistry and Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Nutrition research center, Department of Food Science and Technology, Student Research committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Purpose: This trial was conducted to evaluate the effects of oligofructose-enriched inulin on some of cardiovascular disease risk factors in women with type 2 diabetes.

Methods: 52 females (25<BMI<35 kg/m2) with type 2 diabetes were randomly assigned to two groups. Participants received 10g/d oligofructose-enriched inulin (n=27) or 10g/d placebo (n=25) for 8 weeks. Fasting blood samples were taken to measure metabolic profiles, malondialdehyd and antioxidant enzymes at baseline and after the 8 weeks intervention. Paired, unpaired sample t-test and analysis of covariance were used to comparison of quantitative variables.

Results: After 8 weeks, in the oligofructose-enriched inulin group there was a significant increase in total antioxidant capacity (0.2 mmol/l, 20.0%) and a significant decrease in fasting plasma glucose (19.2 mg/dL, 9.4%) HbA1c (0.5%, 8.4%), total cholesterol (TC) (28.0 mg/dL, 14.1%), low-density lipoprotein cholesterol (LDL-c) (22.0 mg/dL, 21.7%), TC/HDL-c ratio (0.73, 20.7%), LDL-c/HDL-c ratio (0.55, 27.5%) and malondialdehyd (1.7 nmol/ml, 39.7%) compared to the placebo group. Changes in concentrations of triglycerides, high-density lipoprotein cholesterol (HDLc), superoxide dismutase, catalase and glutathione peroxidase were not significant in oligofructose-enriched inulin group compared to the placebo group.

Conclusion: Oligofructose-enriched inulin may improve glycemic indices, lipid profile, antioxidant status and malondialdehyd in women with type 2 diabetes.

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