Adv Pharm Bull. 2014;4(6):527-531.
doi: 10.5681/apb.2014.078
PMID: 25671185
PMCID: PMC4312401
Scopus id: 84921964471
  Abstract View: 402
  PDF Download: 189

Original Research

Anticholinesterase and Antityrosinase Activities of Ten Piper Species from Malaysia

Wan Mohd Nuzul Hakimi Wan Salleh 1, Nur Athirah Hashim 1, Farediah Ahmad 2 * , Khong Heng Yen 1

1 Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia.
2 School of Chemistry and Environmental Studies, Faculty of Applied Sciences, Universiti Teknologi MARA Sarawak, 94300 Kota Samarahan, Sarawak, Malaysia.
Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia. Email:


Purpose: The aim of this study was to investigate acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and antityrosinase activities of extracts from ten Piper species namely; P. caninum, P. lanatum, P. abbreviatum, P. aborescens, P. porphyrophyllum, P. erecticaule, P. ribesioides, P. miniatum, P. stylosum, and P. majusculum. Methods: Anticholinesterase and antityrosinase activities were evaluated against in vitro Ellman spectroscopy method and mushroom tyrosinase, respectively. Results: The EtOAc extract of P. erecticaule showed the highest AChE and BChE inhibitory with 22.9% and 70.9% inhibition, respectively. In antityrosinase activity, all extracts of P. porphyrophyllum showed the highest inhibitory effects against mushroom tyrosinase, compared to standard, kojic acid. Conclusion: This study showed that P. erecticaule and P. porphyrophyllum have potential AChE/BChE and tyrosinase inhibition activities. The respective extracts can be explored further for the development of novel lead as AChE/BChE and tyrosinase inhibitors in therapeutic management of Alzheimer’s disease.
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Submitted: 20 Apr 2014
Revised: 27 May 2014
First published online: 31 Oct 2014
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