Adv Pharm Bull. 2015;5(2):209-216.
doi: 10.15171/apb.2015.029
PMID: 26236659
PMCID: PMC4517077
Scopus id: 84930402125
  Abstract View: 422
  PDF Download: 190

Original Research

Therapeutic Efficacy of Orally Delivered Doxorubicin Nanoparticles in Rat Tongue Cancer Induced by 4-Nitroquinoline 1-Oxide

Monir Moradzadeh Khiavi 1, Ahamd Rostami 2, Hamed Hamishekar 3, Mehran Mesgari Abassi 3, Amirala Aghbali 2, Roya Salehi 3, Bita Abdollahi 3, Soheila Fotoohi 3, Mahmud Sina 2

1 Department of Oral and Maxillofacial Pathology, School of Dentistry, Tehran University of Medical Sciences, International campus, Tehran, Iran.
2 Department of Oral and Maxillofacial Pathology, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Purpose: Oral cancer is one of the most significant cancers in the world, and squamous cell carcinoma makes up about 94% of oral malignancies. The aim of the present study was to compare the efficacy of doxorubicin plus methotrexate - loaded nanoparticles on tongue squamous cell carcinoma induced by 4NQO and compare it with the commercial doxorubicin and methotrexate delivered orally on seventy SD male rats. Methods: 70 rats were divided into five groups. During the study, the animals were weighed by a digital scale once a week. Number of mortalities was recorded in the data collection forms. At the end of the treatment, biopsy samples were taken from rat tongues in order to evaluate the severity of dysplasia and the extent of cell proliferation. The results were analyzed using ANOVA, descriptive statistics and chi-square test. Results: No statistically significant difference was found in the mean weight of five groups (p>0.05). No significant relationship was found between groups and mortality rate (P = 0. 39). In addition, there was a significant relationship between groups and the degree of dysplasia (P <0.001). The statistical analysis showed a significant relationship between groups and the rate of cell proliferation (p <0.001). Conclusion: The results of the present study showed that the use of doxorubicin plus methotrexate - loaded nanoparticles orally had more therapeutic effects than commercial doxorubicin plus methotrexate.
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