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CiteScore (2016): 2.10

SNIP (2016): 1.075

SJR (2016): 0.61

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Adv Pharm Bull. 2015;5(3):293-298.
doi: 10.15171/apb.2015.041

Scopus id: 84983590186
  Abstract View: 398
  PDF Download: 230

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Methods of Liver Stem Cell Therapy in Rodents as Models of Human Liver Regeneration in Hepatic Failure

Nasser Hashemi Goradel 1, Masoud Darabi 2 * , karim Shamsasenjan 3, Mostafa Ejtehadifar 4, Sarah zahedi 4

1 Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Iran Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tabriz, Iran.
4 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


Cell therapy is a promising intervention for treating liver diseases and liver failure. Different animal models of human liver cell therapy have been developed in recent years. Rats and mice are the most commonly used liver failure models. In fact, rodent models of hepatic failure have shown significant improvement in liver function after cell infusion. With the advent of stem-cell technologies, it is now possible to re-programme adult somatic cells such as skin or hair-follicle cells from individual patients to stem-like cells and differentiate them into liver cells. Such regenerative stem cells are highly promising in the personalization of cell therapy. The present review article will summarize current approaches to liver stem cell therapy with rodent models. In addition, we discuss common cell tracking techniques and how tracking data help to direct liver cell therapy research in animal models of hepatic failure.
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Submitted: 29 Oct 2014
Revised: 07 Dec 2014
First published online: 19 Sep 2015
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