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Adv Pharm Bull. 2017;7(1):109-114.
doi: 10.15171/apb.2017.014
PMID: 28507944
PMCID: PMC5426722
Scopus id: 85017571294
  Abstract View: 145
  PDF Download: 209

Research Article

A Survey on Phytochemical Composition and Biological Activity of Zygophyllum fabago from Iran

Saeid Yaripour 1,2, Mohammad-Reza Delnavazi 3, Parina Asgharian 4,5, Samira Valiyari 6, Saeed Tavakoli 3, Hossein Nazemiyeh 7,5 *

1 Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
2 Department of Pharmaceutical and Food Control, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
3 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
4 Drug Applied Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Department of Pharmacognosy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
6 Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran.
7 Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Purpose: Zygophyllum fabago L. (Z. fabago) is a widespread perennial herb which is used as a medicinal plant in traditional medicine of Iran, Turkey and China. The present study was a survey on phytochemical constituents and biological activities of this plant.

Methods: Methanolic extract of the roots was fractionated over a C-18 pre-packed cartridge (Sep-pak) and chromatographic separation was performed on a reversed-phase preparative HPLC. Structural elucidation of the isolated compounds was carried out using UV, 1H-NMR and 13C-NMR spectral analyses. Furthermore, the chemical compositions of the essential oil of the aerial parts were identified by GC-MS analysis. Antiproliferative and antioxidant activities of all extracts from aerials were determined by MTT and DPPH assays, respectively.

Results: Phytochemical investigation on the plant roots led to the isolation and identification of two the 60% methanol-water Sep-pak fraction, a prenylated flavone glycoside, 6-C-prenyl-7-O-[ β -D-4'''-O-acetyl-glucopyranosyl-(1'''→2'')-β-D-glucopyranosyl] apigenin, which was named as a Zygocaperoside and also, other flavonoid, was named as the Isorhamnetin -3-O glucoside. None of the extracts showed antiproliferative effect against cancerous cells. However, among the extracts, methanolic extract indicated antioxidant activity. Moreover, essential oils of flowers and leaves of plant have high amounts of sesquiterpene hydrocarbons and diterpenoides.

Conclusion: The results of present study introduce Z. fabago roots as a new source of flavonoid glycosides and suggest it as an appropriate candidate for further pharmacological studies.

 

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