Adv Pharm Bull. 2016;6(2):143-151.
doi: 10.15171/apb.2016.021
PMID: 27478775
PMCID: PMC4961971
Scopus id: 84980390587
  Abstract View: 598
  PDF Download: 883

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The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Leila Azhar Shekoufeh Bahari 1,2, Hamed Hamishehkar 2 *

1 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

During the past decade, pharmaceutical science has seen rapid growth in interest for nanoscale materials. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are popular research topics recently introduced as nano-scale drug carriers; they have shown numerous merits in drug delivery. Size is the most important index in a nanocarrier affecting its drug delivery efficiency. The influence of preparation conditions and type of lipidic components on the size of SLN and NLC in comparable states seems to be interesting for researchers who investigate these types of carriers. This review highlights the results of SLN and NLC particle size and size distribution comparisons.
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Submitted: 15 Dec 2015
Revised: 02 May 2016
Accepted: 04 May 2016
First published online: 29 Jun 2016
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