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CiteScore (2016): 2.10

SNIP (2016): 1.075

SJR (2016): 0.61

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Adv Pharm Bull. 2016;6(2):243-250.
doi: 10.15171/apb.2016.033
PMID: 27478787
PMCID: PMC4961983
Scopus id: 84980315604
  Abstract View: 651
  PDF Download: 269

Research Article

Vitamin C for the Prevention of Postoperative Atrial Fibrillation after Cardiac Surgery: A Meta-Analysis

Evangelos Polymeropoulos 1 * , Pantelis Bagos 2, Maria Papadimitriou 3, Ioannis Rizos 4, Efstratios Patsouris 5, Ioannis Toumpoulis 6

1 Cardiology Department Red Cross Hospital, Athens, Greece.
2 Department of Computer Science and Biomedical Informatics, University of Thessaly, Lamia, Greece.
3 Internal Medicine Department, Laiko Hospital, Athens, Greece.
4 Cardiology Department, Attiko Hospital, Athens, Greece.
5 Department of Pathology, Medical School of the National University of Athens, Greece.
6 Cardiac Surgery Department, Attiko Hospital, Athens, Greece.

Abstract

Purpose: Several studies have investigated the administration of vitamin C (vitC) for the prevention of postoperative atrial fibrillation (AF) after cardiac surgery. However, their findings were inconsistent. The purpose of this meta-analysis was to evaluate the efficacy of vitC as prophylaxis for the prevention of postoperative AF in cardiac surgery.

Methods: A systematic search of PubMed, EMBASE, Google Scholar, the Cochrane Library, and clinical trial registries, was performed. 9 studies, published from August 2001 to May 2015, were included, with a total of 1,037 patients. Patients were randomized to receive vitC, or placebo.

Results: Cardiac surgery patients who received vitC as prophylaxis, had a significantly lower incidence of postoperative AF (random effects OR=0.478, 95% CI 0.340 – 0.673, P < 10-4). No significant heterogeneity was detected across the analyzed studies (I2=21.7%), and no publication bias or other small study-related bias was found.

Conclusion: Our findings suggest that VitC is effective as prophylaxis for the prevention of postoperative AF. The administration of vitC may be considered in all patients undergoing cardiac surgery.

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