Adv Pharm Bull. 2017;7(1):151-157.
doi: 10.15171/apb.2017.019
PMID: 28507949
PMCID: PMC5426728
Scopus id: 85017551904
  Abstract View: 265
  PDF Download: 170

Research Article

Voltammetric Determination of Ivabradine Hydrochloride Using Multiwalled Carbon Nanotubes Modified Electrode in Presence of Sodium Dodecyl Sulfate

Ali Kamal Attia 1 * , Nisreen Farouk Abo-Talib 1, Marwa Hosny Tammam 1

1 National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt.


Purpose: A new sensitive sensor was fabricated for the determination of ivabradine hydrochloride (IH) based on modification with multiwalled carbon nanotubes using sodium dodecyl sulfate as micellar medium to increase the sensitivity.

Methods: The electrochemical behavior of IH was studied in Britton-Robinson buffer (pH: 2.0-11.0) using cyclic and differential pulse voltammetry.

Results: The voltammetric response was linear over the range of 3.984 x 10-6-3.475 x 10-5 mol L-1. The limits of detection and quantification were found to be 5.160 x 10-7 and 1.720 x 10-6 mol L-1, respectively.

Conclusion: This method is suitable for determination of IH in tablets and plasma.

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Submitted: 03 Jul 2016
Revised: 10 Mar 2017
Accepted: 04 Apr 2017
First published online: 13 Apr 2017
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