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CiteScore (2016): 2.10

SNIP (2016): 1.075

SJR (2016): 0.61

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Adv Pharm Bull. 2016;6(4):573-579.
doi: 10.15171/apb.2016.071
PMID: 28101464
PMCID: PMC5241415
Scopus id: 85011361628
  Abstract View: 260
  PDF Download: 243

Research Article

Anti-Inflammatory and Antibothropic Properties of Jatropha Elliptica, a Plant from Brazilian Cerrado Biome

Sára Costa Ferreira-Rodrigues 1, Cássio Milhomens Rodrigues 1, Marcio Galdino Dos Santos 1, Jean Antonio Abraham Gautuz 2, Magali Glauzer Silva 2, José Carlos Cogo 3, Camila Batista-Silva 4, Cleiton Pita Dos Santos 4, Francisco Carlos Groppo 4, Karina Cogo-Müller 4,5, Yoko Oshima-Franco 2 *

1 Environmental Sciences Post-Graduate Program, PGCiamb, Tocantins Federal University (UFT), Palmas, Tocantins, Brazil.
2 Post-Graduate Program in Pharmaceutical Sciences and Pharmacy, University of Sorocaba (UNISO), Sorocaba, SP, Brazil.
3 Post-Graduate Program in Animal Production, University Camilo Castelo Branco (UNICASTELO), Descalvado, SP, Brazil.
4 Piracicaba Dental School, Department of Pharmacology, University of Campinas (UNICAMP), Piracicaba, SP Brazil.
5 Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Rua Sérgio Buarque de Holanda, Campinas, SP, Brazil.

Abstract

Purpose: The aim of this study was to evaluate the antibothropic and anti-inflammatory properties of J. elliptica. Methods: Phytochemical screening and thin-layer chromatography (TLC) assays were performed on J. elliptica hydroalcoholic extract (TE) in order to observe its main constituents. The antibothropic activity of TE was evaluated by the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu), in a mouse phrenic nerve-diaphragm model (PND). A quantitative histological study was carried out to observe a possible protection of TE against the venom myotoxicity. The anti-inflammatory activity was also evaluated in two models, Bjssu-induced paw edema, and carrageenan-induced neutrophils migration in the peritoneal cavity. Results: TLC analysis revealed several compounds in TE, such as saponins, alkaloids, and phenolic constituents. TE was able to neutralize the blockade and the myotoxicity induced by venom, when it was pre-incubated for 30 min with venom. In addition, it showed anti-inflammatory activity, inducing less neutrophils migration and reducing paw edema. Conclusion: J. elliptica showed both antibothropic and anti-inflammatory properties.
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