Adv Pharm Bull. 2015;5(5):599-603.
doi: 10.15171/apb.2015.081
PMID: 26793604
PMCID: PMC4708029
Scopus id: 84954116938
  Abstract View: 477
  PDF Download: 223


New Approaches to the Immunotherapy of Type 1 Diabetes Mellitus Using Interleukin-27

Fatemeh Zamani 1,2, Shohreh Almasi 1,2, Tohid Kazemi 1,2, Rana Jahanban Esfahlan 3, Mohammad Reza Aliparasti 4 *

1 Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Department of Medical Biotechnology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


Type 1 diabetes (T1D) is a pancreatic beta cell specific autoimmune disease. One of the most significant current discussions in T1D studies is therapy. Since the conventional therapy, islet transplantation and external insulin, e.g., cannot prevent the destructive autoimmune process against original beta cells and persistent hyperglycemia remains, so recent developments in the field of T1D therapy paved the way to a renewed interest in immunotherapy based on the disease process, especially monoclonal antibody therapy. Due to encouraging laboratory results, cytokine antibody-based drugs could be effective in the clinical direction of the T1D disease process. Hence, implementation of this approach can be useful to improve clinical and laboratory manifestations of T1D.
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Submitted: 07 Apr 2014
Revised: 22 Jun 2014
Accepted: 02 Jul 2014
First published online: 31 Dec 2015
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