Adv Pharm Bull. 2015;5(2):151-159.
doi: 10.15171/apb.2015.022
PMID: 26236652
PMCID: PMC4517084
Scopus id: 84930406839
  Abstract View: 571
  PDF Download: 290

Original Research

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Jafar Ezzati Nazhad Dolatabadi 1,2, Hadi Valizadeh 3,4 * , Hamed Hamishehkar 3

1 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

In recent years, nanomaterials have been widely applied as advanced drug and gene delivery nanosystems. Among them, solid lipid nanoparticles (SLNs) have attracted great attention as colloidal drug delivery systems for incorporating hydrophilic or lipophilic drugs and various macromolecules as well as proteins and nucleic acids. Therefore, SLNs offer great promise for controlled and site specific drug and gene delivery. This article includes general information about SLN structures and properties, production procedures, characterization. In addition, recent progress on development of drug and gene delivery systems using SLNs was reviewed.
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Submitted: 13 Sep 2014
Revised: 01 Nov 2014
First published online: 01 Jun 2015
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