Adv Pharm Bull. 2015;5(3):299-304.
doi: 10.15171/apb.2015.042
PMID: 26504750
PMCID: PMC4616896
Scopus id: 84983573811
  Abstract View: 437
  PDF Download: 330

Review Article

The Impact of Mesenchymal Stem Cells on Differentiation of Hematopoietic Stem Cells

Mahshid Saleh 1, karim Shamsasanjan 1,2 * , Aliakbar Movassaghpourakbari 1, Parvin Akbarzadehlaleh 3, Zahra Molaeipour 1

1 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
3 Department of Pharmaceutical Biotechnology, Tabriz University of Medical Science, Tabriz, Iran.


Bone marrow microenvironment contains cellular and acellular compartments. The cellular compartment includes hematopoietic stem cells, mesenchymal stem cells and some other stromal cell types, while the acellular compartment is composed of scaffold proteins known as the extra cellular matrix. Direct cell-cell contact as well as cytokines secreted by mesenchymal stem cells during coculture of hematopoietic stem cells and mesenchymal stem cells play a critical role in hematopoiesis, and determines the fate of hematopoietic stem cells. Several studies have demonstrated the impact of mesenchymal stem cells on self-renewal, expansion, proliferation and differentiation of hematopoietic stem cells in vitro, which have shown different and contradictory results. In this paper, we will investigate the effect of mesenchymal stem cells on differentiation of hematopoietic stem cells in vitro.
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