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Adv Pharm Bull. 2017;7(2): 165-177.
doi: 10.15171/apb.2017.021
PMID: 28761818
PMCID: PMC5527230
Scopus ID: 85021389670
  Abstract View: 2625
  PDF Download: 1437

Review Article

Effects of Mesenchymal Stem Cell Derivatives on Hematopoiesis and Hematopoietic Stem Cells

Sara Aqmasheh 1, karim Shamsasanjan 1*, Parvin Akbarzadehlaleh 2, Davod Pashoutan Sarvar 1, Hamzeh Timari 1

1 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Author: Email: k.shams@ibto.ir

Abstract

Hematopoiesis is a balance among quiescence, self-renewal, proliferation, and differentiation, which is believed to be firmly adjusted through interactions between hematopoietic stem and progenitor cells (HSPCs) with the microenvironment. This microenvironment is derived from a common progenitor of mesenchymal origin and its signals should be capable of regulating the cellular memory of transcriptional situation and lead to an exchange of stem cell genes expression. Mesenchymal stem cells (MSCs) have self-renewal and differentiation capacity into tissues of mesodermal origin, and these cells can support hematopoiesis through release various molecules that play a crucial role in migration, homing, self-renewal, proliferation, and differentiation of HSPCs. Studies on the effects of MSCs on HSPC differentiation can develop modern solutions in the treatment of patients with hematologic disorders for more effective Bone Marrow (BM) transplantation in the near future. However, considerable challenges remain on realization of how paracrine mechanisms of MSCs act on the target tissues, and how to design a therapeutic regimen with various paracrine factors in order to achieve optimal results for tissue conservation and regeneration. The aim of this review is to characterize and consider the related aspects of the ability of MSCs secretome in protection of hematopoiesis.
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Submitted: 06 Nov 2016
Revision: 08 Apr 2017
Accepted: 18 Apr 2017
ePublished: 30 Jun 2017
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