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Adv Pharm Bull. 2018;8(2): 331-339. doi: 10.15171/apb.2018.038
PMID: 30023335        PMCID: PMC6046434

Research Article

Protective Effect of Gemfibrozil on Hepatotoxicity Induced by Acetaminophen in Mice: the Importance of Oxidative Stress Suppression

Hojatolla Nikravesh 1,2, Mohammad Javad Khodayar 1,2 * , Masoud Mahdavinia 1,2, Esrafil Mansouri 1,2, Leila Zeidooni 1,2, Fereshteh Dehbashi 1

Cited by CrossRef: 21


1- Juarez Olg H, Calderon G D, Osnaya Bri N, Ortiz Herr M, Chá J, Veloz Coro Q, Trujillo J F. Some NSAIDs Offer Antioxidant Effect in the Brain Only in Combination with Other Antioxidant Products. International J of Pharmacology. 2021;17(6):350 [Crossref]
2- Karimi M, Goudarzi M, Khodayar M, Khorsandi L, Mehrzadi S, Fatemi I. Gemfibrozil palliates adriamycin-induced testicular injury in male rats via modulating oxidative, endocrine and inflammatory changes in rats. Tissue and Cell. 2023;82:102037 [Crossref]
3- Hashim Mohammed Y, Hassan A. Analyzing the Potential Antioxidative Effects of Omega-369 in Preventing Acetaminophen-Induced Liver Damage. Al-Rafidain J Med Sci. 2023;4:73 [Crossref]
4- Thida M, Li B, Zhang X, Chen C, Zhang X. Echinacoside alleviates acetaminophen-induced liver injury by attenuating oxidative stress and inflammatory cytokines in mice. J Appl Biomed. 2021;19(2):105 [Crossref]
5- Thongnak L, Pengrattanachot N, Promsan S, Phengpol N, Sutthasupha P, Jaikumkao K, Lungkaphin A. Metformin mitigates renal dysfunction in obese insulin-resistant rats via activation of the AMPK/PPARα pathway. Arch Pharm Res. 2023;46(5):408 [Crossref]
6- Li Q, Zhang W, Cheng N, Zhu Y, Li H, Zhang S, Guo W, Ge G. Pectolinarigenin ameliorates acetaminophen-induced acute liver injury via attenuating oxidative stress and inflammatory response in Nrf2 and PPARa dependent manners. Phytomedicine. 2023;113:154726 [Crossref]
7- Tan J, Li J, Ma J, Qiao F. Hepatoprotective effect of essential oils of Nepeta cataria L. on acetaminophen-induced liver dysfunction. 2019;39(8) [Crossref]
8- Ishtiaq S, Rashid H, Hussain Z, Arshad M, Khan J. Adiponectin and PPAR: a setup for intricate crosstalk between obesity and non-alcoholic fatty liver disease. Rev Endocr Metab Disord. 2019;20(3):253 [Crossref]
9- Zhao P, Liu X, Jiang W, Wu P, Liu Y, Ren H, Jin X, Zhang L, Mi H, Feng L, Zhou X. Novel insights on toxicology of ochratoxin A contaminated diets to skin: Residues, mucus disruption and barrier impairment in teleost model grass carp (Ctenopharyngodon idella). Ecotoxicology and Environmental Safety. 2023;262:115153 [Crossref]
10- Sadeghinejad S, Mousavi M, Zeidooni L, Mansouri E, Mohtadi S, Khodayar M. Ameliorative effects of umbelliferone against acetaminophen-induced hepatic oxidative stress and inflammation in mice. 2024;19(1):83 [Crossref]
11- Ogino N, Nagaoka K, Tomizuka K, Matsuura-Harada Y, Eitoku M, Suganuma N, Ogino K. Compromised glutathione synthesis results in high susceptibility to acetaminophen hepatotoxicity in acatalasemic mice. Food and Chemical Toxicology. 2021;156:112509 [Crossref]
12- Hakimizadeh E, Tadayon S, Zamanian M, Soltani A, Giménez‐Llort L, Hassanipour M, Fatemi I. Gemfibrozil, a lipid‐lowering drug, improves hepatorenal damages in a mouse model of aging. Fundamemntal Clinical Pharma. 2023;37(3):599 [Crossref]
13- Hosseinzadeh A, Goudarzi M, Fatemi I, Khodayar M, Mehrzadi S, Khalili H, Karimi M. Gemfibrozil attenuates doxorubicin induced toxicity in renal tissues of male rats by reducing the oxidative insult and inflammation. Biotechnic & Histochemistry. 2020;95(7):532 [Crossref]
14- Latif A, Assar D, Elkaw E, Hamza H, Alkhalifah D, Hozzein W, Hamouda R. Protective role of Chlorella vulgaris with Thiamine against Paracetamol induced toxic effects on haematological, biochemical, oxidative stress parameters and histopathological changes in Wistar rats. Sci Rep. 2021;11(1) [Crossref]
15- Jiang Z, Guo X, Zhang K, Sekaran G, Cao B, Zhao Q, Zhang S, Kirby G, Zhang X. The Essential Oils and Eucalyptol From Artemisia vulgaris L. Prevent Acetaminophen-Induced Liver Injury by Activating Nrf2–Keap1 and Enhancing APAP Clearance Through Non-Toxic Metabolic Pathway. Front Pharmacol. 2019;10 [Crossref]
16- Shamlan G. Ethanolic and Aqueous Extracts of Avocado (Persea americana) Seeds Attenuates Doxorubicin-Induced Cardiotoxicity in Male Albino Rats. Arab J Sci Eng. 2021;46(6):5265 [Crossref]
17- Bavandipour A, Jangravi Z, Kondori B, Poorheidari G, Salimi-Sabour E, Zarei S. High-Performance Thin-Layer Chromatography Fingerprinting Analysis and Hepatoprotective Effects of Scrophularia striata Aerial Parts Against Acetaminophen-Induced Acute Hepatotoxicity in Mice. Pharm Chem J. 2023;57(9):1476 [Crossref]
18- Haybar H, Goudarzi M, Mehrzadi S, Aminzadeh A, Khodayar M, Kalantar M, Fatemi I. Effect of gemfibrozil on cardiotoxicity induced by doxorubicin in male experimental rats. Biomedicine & Pharmacotherapy. 2019;109:530 [Crossref]
19- Shi C, Xue W, Han B, Yang F, Yin Y, Hu C. Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK/mTOR pathway. European Journal of Pharmacology. 2019;850:15 [Crossref]
20- Mullins M, Yeager L, Freeman W. Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review. Clinical Toxicology. 2020;58(12):1284 [Crossref]
21- Ullah H, Lee Y, Kim M, Kim T, Saba E, Kwak Y, Sandhu M, Rhee M, Vergara D. Red Ginseng Oil Attenuates Oxidative Stress and Offers Protection against Ultraviolet-Induced Photo Toxicity. Oxidative Medicine and Cellular Longevity. 2021;2021:1 [Crossref]
22- Mohammed Y, Hassan A. Evaluation the anti-inflammatory effect of Omega 369 against acetaminophen-induced hepatotoxicity in mice. PHAR. 2023;70(3):419 [Crossref]
23- Kalantari H, Asadmasjedi N, Abyaz M, Mahdavinia M, Mohammadtaghvaei N. Protective effect of inulin on methotrexate- induced liver toxicity in mice. Biomedicine & Pharmacotherapy. 2019;110:943 [Crossref]