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Adv Pharm Bull. 2015;5(3): 329-334. doi: 10.15171/apb.2015.046
PMID: 26504754        PMCID: PMC4616901

Original Research

Cytoprotective Effects of Melatonin Against Amitriptyline-Induced Toxicity in Isolated Rat Hepatocytes

Shohreh Taziki 1,2, Mohammad Reza Sattari 3,4, Siavoush Dastamalchi 5, Mohammad Ali Eghbal 6,3 *

Cited by CrossRef: 13


1- Majidinia M, Reiter R, Shakouri S, Yousefi B. The role of melatonin, a multitasking molecule, in retarding the processes of ageing. Ageing Research Reviews. 2018;47:198 [Crossref]
2- Solek P, Koszla O, Mytych J, Badura J, Chelminiak Z, Cuprys M, Fraczek J, Tabecka-Lonczynska A, Koziorowski M. Neuronal life or death linked to depression treatment: the interplay between drugs and their stress-related outcomes relate to single or combined drug therapies. Apoptosis. 2019;24(9-10):773 [Crossref]
3- Zhang J, Yan X, Tian Y, Li W, Wang H, Li Q, Li Y, Li Z, Wu T. Synthesis of a New Water-Soluble Melatonin Derivative with Low Toxicity and a Strong Effect on Sleep Aid. ACS Omega. 2020;5(12):6494 [Crossref]
4- Esteban-Zubero E, Alatorre-Jiménez M, López-Pingarrón L, Reyes-Gonzales M, Almeida-Souza P, Cantín-Golet A, Ruiz-Ruiz F, Tan D, García J, Reiter R. Melatonin’s role in preventing toxin-related and sepsis-mediated hepatic damage: A review. Pharmacological Research. 2016;105:108 [Crossref]
5- Khalili Fard J, Hamzeiy H, Sattari M, Eghbal M. Protective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced Hepatotoxicity. Adv Pharm Bull. 2016;6(4):627 [Crossref]
6- Collin A, Kohan R, Tolosa de Talamoni N, Picotto G. Melatonin Enhances Anti-tumoral Effects of Menadione on Colon Cancer Cells. ACAMC. 2022;22(13):2411 [Crossref]
7- Demidchik L, Lee V, Klyuyev D, Bakirova R, Molotov-Luchanskiy V, Pozdnyakova Y, Beinikova I, Bobyrev S. Serum Neutrophil Gelatinase Associated Lipocalin in Patients with Toxic Nephropathies. Prospective Study. Annals RAMS. 2021;76(2):142 [Crossref]
8- Khatab L, Abdel-Raheem I, Ghoneim A. Protective effects of melatonin and l-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes. Naunyn-Schmiedeberg's Arch Pharmacol. 2022;395(1):87 [Crossref]
9- NaveenKumar S, Hemshekhar M, Kemparaju K, Girish K. Hemin-induced platelet activation and ferroptosis is mediated through ROS-driven proteasomal activity and inflammasome activation: Protection by Melatonin. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2019;1865(9):2303 [Crossref]
10- Hyun M, Kim H, Kim J, Lee J, Lee H, Rathor L, Meier J, Larner A, Lee S, Moon Y, Choi J, Han S, Heo J. Melatonin protects against cadmium-induced oxidative stress via mitochondrial STAT3 signaling in human prostate stromal cells. Commun Biol. 2023;6(1) [Crossref]
11- Aygun H, Basol N, Gul S. Cardioprotective Effect of Paricalcitol on Amitriptyline-Induced Cardiotoxicity in Rats: Comparison of [99mTc]PYP Cardiac Scintigraphy with Electrocardiographic and Biochemical Findings. Cardiovasc Toxicol. 2020;20(4):427 [Crossref]
12- Eftekhari A, Ahmadian E, Azarmi Y, Parvizpur A, Hamishehkar H, Eghbal M. In vitro/vivo studies towards mechanisms of risperidone-induced oxidative stress and the protective role of coenzyme Q10 and N-acetylcysteine. Toxicology Mechanisms and Methods. 2016;26(7):520 [Crossref]