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Adv Pharm Bull. 2017;7(2): 241-249. doi: 10.15171/apb.2017.029
PMID: 28761826        PMCID: PMC5527238

Research Article

The Inhibitory Effect of Ginger Extract on Ovarian Cancer Cell Line; Application of Systems Biology

Roghiyeh Pashaei-Asl 1,2, Fatima Pashaei-Asl 3, Parvin Mostafa Gharabaghi 4 * , Khodadad Khodadadi 5, Mansour Ebrahimi 6, Esmaeil Ebrahimie 7,8,9,10, Maryam Pashaiasl 4,11,12 *

Cited by CrossRef: 29


1- Thao D, Nga N, Van N, Hung K. Potential Anticancer Activities of a Combination of Curcumin, Ginger Oleoresin, and Rutin Solid Lipid Nanoparticles (Vietlife-Antican) in LLC Tumor-Bearing Mice. Natural Product Communications. 2019;14(6):1934578X1985846 [Crossref]
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4- Mohd Sahardi N, Makpol S. Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence. Evidence-Based Complementary and Alternative Medicine. 2019;2019:1 [Crossref]
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9- Farmoudeh A, Shokoohi A, Ebrahimnejad P. Preparation and Evaluation of the Antibacterial Effect of Chitosan Nanoparticles Containing Ginger Extract Tailored by Central Composite Design. Adv Pharm Bull. 2020;11(4):643 [Crossref]
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14- Al-Janabi A, Hayati Roodbari N, Homayouni Tabrizi M. Investigating the anticancer and anti-angiogenic effects of graphene oxide nanoparticles containing 6-gingerol modified with chitosan and folate. Cancer Nano. 2023;14(1) [Crossref]
15- Mohd Sahardi N, Jaafar F, Tan J, Mad Nordin M, Makpol S. Elucidating the Pharmacological Properties of Zingiber officinale Roscoe (Ginger) on Muscle Ageing by Untargeted Metabolomic Profiling of Human Myoblasts. Nutrients. 2023;15(21):4520 [Crossref]
16- Govic A, Nasser H, Levay E, Zelko M, Ebrahimie E, Mohammadi Dehcheshmeh M, Kent S, Penman J, Hazi A. Long-Term Calorie Restriction Alters Anxiety-like Behaviour and the Brain and Adrenal Gland Transcriptomes of the Ageing Male Rat. Nutrients. 2022;14(21):4670 [Crossref]
17- Alanazi I, Al Shehri Z, Ebrahimie E, Giahi H, Mohammadi‐Dehcheshmeh M. Non‐coding and coding genomic variants distinguish prostate cancer, castration‐resistant prostate cancer, familial prostate cancer, and metastatic castration‐resistant prostate cancer from each other. Molecular Carcinogenesis. 2019;58(6):862 [Crossref]
18- Zadorozhna M, Mangieri D. Mechanisms of Chemopreventive and Therapeutic Proprieties of Ginger Extracts in Cancer. IJMS. 2021;22(12):6599 [Crossref]
19- Rahmatizadeh F, Gholizadeh-Ghaleh Aziz S, Khodadadi K, Lale Ataei M, Ebrahimie E, Soleimani Rad J, Pashaiasl M. Bidirectional and Opposite Effects of Naïve Mesenchymal Stem Cells Ontumor Growth and Progression. Adv Pharm Bull. 2019;9(4):539 [Crossref]
20- Park S, Jung S, Choi E, Ha K, Baek H, Park Y, Han K, Jeong S, Oh J, Cha Y, Park B, Chae S. The effects of steamed ginger ethanolic extract on weight and body fat loss: a randomized, double-blind, placebo-controlled clinical trial. Food Sci Biotechnol. 2020;29(2):265 [Crossref]
21- Farhadian M, Rafat S, Hasanpur K, Ebrahimi M, Ebrahimie E. Cross-Species Meta-Analysis of Transcriptomic Data in Combination With Supervised Machine Learning Models Identifies the Common Gene Signature of Lactation Process. Front Genet. 2018;9 [Crossref]
22- Alanazi I, AlYahya S, Ebrahimie E, Mohammadi-Dehcheshmeh M. Computational systems biology analysis of biomarkers in lung cancer; unravelling genomic regions which frequently encode biomarkers, enriched pathways, and new candidates. Gene. 2018;659:29 [Crossref]
23- Talib W, AL-ataby I, Mahmod A, Jawarneh S, Al Kury L, AL-Yasari I. The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood. Molecules. 2020;25(18):4207 [Crossref]
24- Almatroudi A, Alsahli M, Alrumaihi F, Allemailem K, Rahmani A. Ginger: A Novel Strategy to Battle Cancer through Modulating Cell Signalling Pathways: A Review. CPB. 2019;20(1):5 [Crossref]
25- Liang T, He Y, Chang Y, Liu X. 6-shogaol a Active Component from Ginger Inhibits Cell Proliferation and Induces Apoptosis through Inhibition of STAT-3 Translocation in Ovarian Cancer Cell Lines (A2780). Biotechnol Bioproc E. 2019;24(3):560 [Crossref]
26- Crichton M, Marshall S, Marx W, Isenring E, Lohning A. Therapeutic health effects of ginger (Zingiber officinale): updated narrative review exploring the mechanisms of action. 2023;81(9):1213 [Crossref]
27- Zhao K, Ebrahimie E, Mohammadi-Dehcheshmeh M, Lewsey M, Zheng L, Hoogenraad N. Transcriptomic signature of cancer cachexia by integration of machine learning, literature mining and meta-analysis. Computers in Biology and Medicine. 2024;172:108233 [Crossref]
28- Kahroba H, Shirmohamadi M, Hejazi M, Samadi N. The Role of Nrf2 signaling in cancer stem cells: From stemness and self-renewal to tumorigenesis and chemoresistance. Life Sciences. 2019;239:116986 [Crossref]
29- Ahsan R, Tahsili M, Ebrahimi F, Ebrahimie E, Ebrahimi M. Image processing unravels the evolutionary pattern of SARS-CoV-2 against SARS and MERS through position-based pattern recognition. Computers in Biology and Medicine. 2021;134:104471 [Crossref]