Modulation of Cytokine Production and Transcription Factors Activities in Human Jurkat T Cells by Thymol and Carvacrol

Nasser Gholijani ¹, Marjan Gharagozloo ^2,3, Fathollah Kalantar ⁴, Amin Ramezani ^5,6, Zahra Amirghofran ^4,7 *

Cited by CrossRef: 32

1- García-Salinas S, Evangelopoulos M, Gámez-Herrera E, Arruebo M, Irusta S, Taraballi F, Mendoza G, Tasciotti E. Electrospun anti-inflammatory patch loaded with essential oils for wound healing. International Journal of Pharmaceutics. 2020;577:119067 [Crossref]

2- Imran M, Aslam M, Alsagaby S, Saeed F, Ahmad I, Afzaal M, Arshad M, Abdelgawad M, El‐Ghorab A, Khames A, Shariati M, Ahmad A, Hussain M, Imran A, Islam S. Therapeutic application of carvacrol: A comprehensive review. Food Science & Nutrition. 2022;10(11):3544 [Crossref]

3- Khazdair M, Ghorani V, Alavinezhad A, Boskabady M. Pharmacological effects of Zataria multiflora Boiss L. and its constituents focus on their anti‐inflammatory, antioxidant, and immunomodulatory effects. Fundamemntal Clinical Pharma. 2018;32(1):26 [Crossref]

4- Ismail H. The ameliorative efficacy of Thymus vulgaris essential oil against Escherichia coli O157:H7-induced hematological alterations, hepatorenal dysfunction and immune-inflammatory disturbances in experimentally infected rats. Environ Sci Pollut Res. 2022;29(27):41476 [Crossref]

5- Gholijani N, Amirghofran Z. Effects of thymol and carvacrol on T-helper cell subset cytokines and their main transcription factors in ovalbumin-immunized mice. Journal of Immunotoxicology. 2016;13(5):729 [Crossref]

6- AL-Ataby I, Talib W. Wild Thyme Herbal Infusion Consumption Suppresses Tumor Growth in a Murine Model of Breast Cancer. CST. 2022;17(2) [Crossref]

7- Islam M, Khalipha A, Bagchi R, Mondal M, Smrity S, Uddin S, Shilpi J, Rouf R. Anticancer activity of thymol: A literature‐based review and docking study with Emphasis on its anticancer mechanisms. IUBMB Life. 2019;71(1):9 [Crossref]

8- Grazul M, Kwiatkowski P, Hartman K, Kilanowicz A, Sienkiewicz M. How to Naturally Support the Immune System in Inflammation—Essential Oils as Immune Boosters. Biomedicines. 2023;11(9):2381 [Crossref]

9- Nosoudi N, Hasanzadeh A, Hart M, Weaver B. Advancements and Future Perspectives in Cell Electrospinning and Bio‐Electrospraying. Advanced Biology. 2023;7(10) [Crossref]

10- Bayat M, Kalantar K, Amirghofran Z. Inhibition of interferon-γ production and T-bet expression by menthol treatment of human peripheral blood mononuclear cells. Immunopharmacology and Immunotoxicology. 2019;41(2):267 [Crossref]

11- Tripathy S, Verma D, Thakur M, Patel A, Srivastav P, Singh S, Chávez-González M, Aguilar C. Encapsulated Food Products as a Strategy to Strengthen Immunity Against COVID-19. Front Nutr. 2021;8 [Crossref]

12- de Groot N, Meneguzzi M, de Souza B, de O. Costa M. In Vitro Screening of Non-Antibiotic Components to Mitigate Intestinal Lesions Caused by Brachyspira hyodysenteriae, Lawsonia intracellularis and Salmonella enterica Serovar Typhimurium. Animals. 2022;12(18):2356 [Crossref]

13- Nagoor Meeran M, Javed H, Al Taee H, Azimullah S, Ojha S. Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development. Front Pharmacol. 2017;8 [Crossref]

14- Kamran S, Sinniah A, Abdulghani M, Alshawsh M. Therapeutic Potential of Certain Terpenoids as Anticancer Agents: A Scoping Review. Cancers. 2022;14(5):1100 [Crossref]

15- Bendary M, Ibrahim D, Mosbah R, Mosallam F, Hegazy W, Awad N, Alshareef W, Alomar S, Zaitone S, Abd El-Hamid M. Thymol Nanoemulsion: A New Therapeutic Option for Extensively Drug Resistant Foodborne Pathogens. Antibiotics. 2020;10(1):25 [Crossref]

16- Wang L, Zhao X, Zhu C, Xia X, Qin W, Li M, Wang T, Chen S, Xu Y, Hang B, Sun Y, Jiang J, Richard L, Lei L, Zhang G, Hu J. Thymol kills bacteria, reduces biofilm formation, and protects mice against a fatal infection of Actinobacillus pleuropneumoniae strain L20. Veterinary Microbiology. 2017;203:202 [Crossref]

17- Puiu R, Bîrcă A, Grumezescu V, Duta L, Oprea O, Holban A, Hudiță A, Gălățeanu B, Balaure P, Grumezescu A, Andronescu E. Multifunctional Polymeric Biodegradable and Biocompatible Coatings Based on Silver Nanoparticles: A Comparative In Vitro Study on Their Cytotoxicity towards Cancer and Normal Cell Lines of Cytostatic Drugs versus Essential-Oil-Loaded Nanoparticles and on Their Antimicrobial and Antibiofilm Activities. Pharmaceutics. 2023;15(7):1882 [Crossref]

18- Saadat S, Aslani M, Ghorani V, Keyhanmanesh R, Boskabady M. The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review. Phytotherapy Research. 2021;35(6):2968 [Crossref]

19- Gan S, Ye J, Li J, Hu C, Wang J, Xu D, Pan X, Chu C, Chu J, Zhang J, Zheng J, Zhang X, Xu J, Zhang H, Qu F, Cui X. LRP11 activates β-catenin to induce PD-L1 expression in prostate cancer. Journal of Drug Targeting. 2020;28(5):508 [Crossref]

20- Tyler S, Tyler L. Pathways to healing: Plants with therapeutic potential for neurodegenerative diseases. IBRO Neuroscience Reports. 2023;14:210 [Crossref]

21- Seibel J, Wonnemann M, Werz O, Lehner M. A tiered approach to investigate the mechanism of anti-inflammatory activity of an herbal medicinal product containing a fixed combination of thyme herb and primula root extracts. Clin Phytosci. 2018;4(1) [Crossref]

22- Mahmoodi M, Ayoobi F, Aghaei A, Rahmani M, Taghipour Z, Hosseini A, Jafarzadeh A, Sankian M. Beneficial effects of Thymus vulgaris extract in experimental autoimmune encephalomyelitis: Clinical, histological and cytokine alterations. Biomedicine & Pharmacotherapy. 2019;109:2100 [Crossref]

23- Niksic H, Becic F, Koric E, Gusic I, Omeragic E, Muratovic S, Miladinovic B, Duric K. Cytotoxicity screening of Thymus vulgaris L. essential oil in brine shrimp nauplii and cancer cell lines. Sci Rep. 2021;11(1) [Crossref]

24- Miladi H, Zmantar T, Chaabouni Y, Fedhila K, Bakhrouf A, Mahdouani K, Chaieb K. Antibacterial and efflux pump inhibitors of thymol and carvacrol against food-borne pathogens. Microbial Pathogenesis. 2016;99:95 [Crossref]

25- Asemani Y, Zamani N, Bayat M, Amirghofran Z. Allium vegetables for possible future of cancer treatment. Phytotherapy Research. 2019;33(12):3019 [Crossref]

26- Zhao L, Wang Y, Mu P, Zhang X, Qi R, Zhang Y, Zhang H, Zhu X, Dong Z, Dong Y. IGFBP3 induces PD-L1 expression to promote glioblastoma immune evasion. Cancer Cell Int. 2024;24(1) [Crossref]

27- Gandhi G, Vasconcelos A, Haran G, Calisto V, Jothi G, Quintans J, Cuevas L, Narain N, Júnior L, Cipolotti R, Gurgel R. Essential oils and its bioactive compounds modulating cytokines: A systematic review on anti-asthmatic and immunomodulatory properties. Phytomedicine. 2020;73:152854 [Crossref]

28- Gholijani N, Hashemi E, Amirghofran Z. Piperine from Black Pepper Decreased the Expression of Intercellular Adhesion Molecule-1 in Macrophages. AIAAMC. 2021;20(2):201 [Crossref]

29- Gabbai‐Armelin P, Sales L, Ferrisse T, De Oliveira A, De Oliveira J, Giro E, Brighenti F. A systematic review and meta‐analysis of the effect of thymol as an anti‐inflammatory and wound healing agent. Phytotherapy Research. 2022;36(9):3415 [Crossref]

30- Lessa R, Ebrahimi B, Li H, Guan X, Li Y, Lu J. Investigation of the In Vitro Immunomodulatory Effects of Extracts from Green-Lipped Mussels (Perna canaliculus). Nutraceuticals. 2024;4(1):127 [Crossref]

31- Sahin D, Kepekci R, Türkmenoğlu B, Akkoc S. Biological evaluations and computational studies of newly synthesized thymol-based Schiff bases as anticancer, antimicrobial and antioxidant agents. Journal of Biomolecular Structure and Dynamics. 2023;:1 [Crossref]

32- Shiratori H, Feinweber C, Luckhardt S, Linke B, Resch E, Geisslinger G, Weigert A, Parnham M. THP-1 and human peripheral blood mononuclear cell-derived macrophages differ in their capacity to polarize in vitro. Molecular Immunology. 2017;88:58 [Crossref]

33- Hajibonabi A, Yekani M, Sharifi S, Nahad J, Dizaj S, Memar M. Antimicrobial activity of nanoformulations of carvacrol and thymol: New trend and applications. OpenNano. 2023;13:100170 [Crossref]

34- Khosravi A, Erle D, Zissel G. Chitin-Induced Airway Epithelial Cell Innate Immune Responses Are Inhibited by Carvacrol/Thymol. PLoS ONE. 2016;11(7):e0159459 [Crossref]