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Adv Pharm Bull. 2015;5(5): 673-681. doi: 10.15171/apb.2015.092
PMID: 26793615        PMCID: PMC4708040

Original Research

Generation of New M2e-HA2 Fusion Chimeric Peptide to Development of a Recombinant Fusion Protein Vaccine

Ali Ameghi 1,2, Behzad Baradaran 3, Khosrow Aghaiypour 4 * , Abolfazl Barzegar 5, Yones Pilehvar-Soltanahmadi 3,6, Masood Moghadampour 2, Morteza Taghizadeh 2, Nosratollah Zarghami 3,1,6 *

Cited by CrossRef: 7


1- Mohajeri A, Abdolalizadeh J, Pilehvar-Soltanahmadi Y, Kiafar F, Zarghami N. Expression and Secretion of Endostar Protein by Escherichia Coli: Optimization of Culture Conditions Using the Response Surface Methodology. Mol Biotechnol. 2016;58(10):634 [Crossref]
2- Stepanova L, Mardanova E, Shuklina M, Blokhina E, Kotlyarov R, Potapchuk M, Kovaleva A, Vidyaeva I, Korotkov A, Eletskaya E, Ravin N, Tsybalova L. Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes. J Biomed Sci. 2018;25(1) [Crossref]
3- Hajam I, Kirthika P, Hewawaduge C, Jawalagatti V, Park S, Senevirathne A, Lee J. Oral immunization with an attenuated Salmonella Gallinarum encoding the H9N2 haemagglutinin and M2 ectodomain induces protective immune responses against H9N2 infection in chickens. Avian Pathology. 2020;49(5):486 [Crossref]
4- Mehrabi M, Sadeghi‐Soureh S, Mohammadpour Dounighi N, Rezayat S, Doroud D, Khoobi M, Amani A. Development and optimisation of hepatitis B recombinant antigen loaded chitosan nanoparticles as an adjuvant using the response surface methodology. Micro & Nano Letters. 2020;15(11):736 [Crossref]
5- Kalaiyarasu S, Bhatia S, Mishra N, Senthil Kumar D, Kumar M, Sood R, Rajukumar K, Ponnusamy B, Desai D, Singh V. Elicitation of Highly Pathogenic Avian Influenza H5N1 M2e and HA2-Specific Humoral and Cell-Mediated Immune Response in Chicken Following Immunization With Recombinant M2e–HA2 Fusion Protein. Front Vet Sci. 2021;7 [Crossref]
6- Wang S, Jiang N, Jiang L, Zhuang Q, Chen Q, Hou G, Xiao Z, Zhao R, Li Y, Zhao C, Zhang F, Yu J, Li J, Liu H, Sun F, Wang K, Gyarmati P. Establishment and application of a quadruple real-time RT-PCR for detecting avian metapneumovirus. PLoS ONE. 2022;17(6):e0270708 [Crossref]
7- Ameghi A, Pilehvar-Soltanahmadi Y, Baradaran B, Barzegar A, Taghizadeh M, Zarghami N, Aghaiypour K. Protective Immunity Against Homologous and Heterologous Influenza Virus Lethal Challenge by Immunization with New Recombinant Chimeric HA2-M2e Fusion Protein in BALB/C Mice. Viral Immunology. 2016;29(4):228 [Crossref]