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Adv Pharm Bull. 2017;7(4): 531-546. doi: 10.15171/apb.2017.065
PMID: 29399543        PMCID: PMC5788208

Review Article

The Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicles on Hematopoietic Stem Cells Fate

Hamze Timari 1, Karim Shamsasenjan 1 * , Aliakbar Movassaghpour 2, Parvin Akbarzadehlaleh 3, Davod Pashoutan Sarvar 1, Sara Aqmasheh 1

Cited by CrossRef: 16


1- banimohamad-shotorbani B, Kahroba H, Sadeghzadeh H, Wilson D, Maadi H, Samadi N, Hejazi M, Farajpour H, Onari B, Sadeghi M. DNA damage repair response in mesenchymal stromal cells: From cellular senescence and aging to apoptosis and differentiation ability. Ageing Research Reviews. 2020;62:101125 [Crossref]
2- Ingavle G, Vaidya A, Kale V. Constructing Three-Dimensional Microenvironments Using Engineered Biomaterials for Hematopoietic Stem Cell Expansion. Tissue Engineering Part B: Reviews. 2019;25(4):312 [Crossref]
3- Shamsasenjan K, Timari H, Saleh M. The effect of mesenchymal stem cell-derived microvesicles on differentiation of umbilical cord blood-derived CD34+ cells toward myeloid lineage. Gene Reports. 2022;26:101462 [Crossref]
4- Arabpour M, Saghazadeh A, Rezaei N. Anti-inflammatory and M2 macrophage polarization-promoting effect of mesenchymal stem cell-derived exosomes. International Immunopharmacology. 2021;97:107823 [Crossref]
5- Preciado S, Muntión S, Corchete L, Ramos T, Torre A, Osugui L, Rico A, Espinosa-Lara N, Gastaca I, Díez-Campelo M, Cañizo C, Sánchez-Guijo F. The Incorporation of Extracellular Vesicles from Mesenchymal Stromal Cells Into CD34+ Cells Increases Their Clonogenic Capacity and Bone Marrow Lodging Ability. 2019;37(10):1357 [Crossref]
6- Gilchrist A, Harley B. Engineered Tissue Models to Replicate Dynamic Interactions within the Hematopoietic Stem Cell Niche. Adv Healthcare Materials. 2022;11(7) [Crossref]
7- Lelek J, Zuba-Surma E. Perspectives for Future Use of Extracellular Vesicles from Umbilical Cord- and Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells in Regenerative Therapies—Synthetic Review. IJMS. 2020;21(3):799 [Crossref]
8- Lia G, Di Vito C, Cerrano M, Brunello L, Calcaterra F, Tapparo M, Giaccone L, Mavilio D, Bruno B. Extracellular Vesicles After Allogeneic Hematopoietic Cell Transplantation: Emerging Role in Post-Transplant Complications. Front Immunol. 2020;11 [Crossref]
9- Batsali A, Georgopoulou A, Mavroudi I, Matheakakis A, Pontikoglou C, Papadaki H. The Role of Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles (MSC-EVs) in Normal and Abnormal Hematopoiesis and Their Therapeutic Potential. JCM. 2020;9(3):856 [Crossref]
10- Preciado S, Muntión S, Sánchez-Guijo F. Improving hematopoietic engraftment: Potential role of mesenchymal stromal cell-derived extracellular vesicles. 2021;39(1):26 [Crossref]
11- Abbaszadeh H, Ghorbani F, Derakhshani M, Abbasi B, Jalili Z, Talebi M, Yousefi M, Shamsasenjan K, Edalati M, Hakimi P, Sanei M, Yaghoubi R, Movassaghpour A. The effect of Acellularized Wharton's Jelly-derived exosomes on myeloid differentiation of umbilical cord blood-derived CD34+ hematopoietic stem cells. Gene Reports. 2021;25:101298 [Crossref]
12- Yaghoubi Y, Zamani M, Naimi A, Hassanzadeh A, Gharibeh N, Madani J, Motevali R, Nikshad A, Aghlmandi A, Parhizkar F, Mehdizadeh A, Nazari M, Yousefi M, Movassaghpour A. Human CD34+ hematopoietic stem cells culture in humanized culture medium for cell therapy. Gene Reports. 2020;20:100718 [Crossref]
13- Vaidya A, Singh S, Limaye L, Kale V. Chimeric feeders of mesenchymal stromal cells and stromal cells modified with constitutively active AKT expand hematopoietic stem cells. Regenerative Medicine. 2019;14(6):535 [Crossref]
14- Ghasemi M, Roshandel E, Mohammadian M, Farhadihosseinabadi B, Akbarzadehlaleh P, Shamsasenjan K. Mesenchymal stromal cell-derived secretome-based therapy for neurodegenerative diseases: overview of clinical trials. Stem Cell Res Ther. 2023;14(1) [Crossref]
15- Gautheron F, Georgievski A, Garrido C, Quéré R. Bone marrow-derived extracellular vesicles carry the TGF-β signal transducer Smad2 to preserve hematopoietic stem cells in mice. Cell Death Discov. 2023;9(1) [Crossref]
16- Wu C, Weng T, Li J, Wu K. Biology and Therapeutic Properties of Mesenchymal Stem Cells in Leukemia. IJMS. 2024;25(5):2527 [Crossref]