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Adv Pharm Bull. 2017;7(1): 11-20. doi: 10.15171/apb.2017.003
PMID: 28507933        PMCID: PMC5426723

Review Article

Novel Pentablock Copolymers as Thermosensitive Self-Assembling Micelles for Ocular Drug Delivery

Mitra Alami-Milani 1,2, Parvin Zakeri-Milani 1,3, Hadi Valizadeh 1,3, Roya Salehi 4, Sara Salatin 1,4, Ali Naderinia 5, Mitra Jelvehgari 1,3 *

Cited by CrossRef: 26


1- Alshememry A, Alkholief M, Abul Kalam M, Raish M, Ali R, Alhudaithi S, Iqbal M, Alshamsan A. Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits. Molecules. 2022;27(14):4619 [Crossref]
2- López Ruiz A, Ramirez A, McEnnis K. Single and Multiple Stimuli-Responsive Polymer Particles for Controlled Drug Delivery. Pharmaceutics. 2022;14(2):421 [Crossref]
3- Alami-Milani M, Zakeri-Milani P, Valizadeh H, Sattari S, Salatin S, Jelvehgari M. Evaluation of anti-inflammatory impact of dexamethasone-loaded PCL-PEG-PCL micelles on endotoxin-induced uveitis in rabbits. Pharmaceutical Development and Technology. 2019;24(6):680 [Crossref]
4- Alami-Milani M, Salatin S, Rayeni F, Jelvehgari M. Preparation and in vitro evaluation of thermosensitive and mucoadhesive hydrogels for intranasal delivery of phenobarbital sodium. Therapeutic Delivery. 2021;12(6):461 [Crossref]
5- Guo L, Xu J, Du B. Self-assembly of ABCBA Linear Pentablock Terpolymers. Polymer Reviews. 2024;64(1):1 [Crossref]
6- Saraei M, Sarvari R, Fakhri E, Fariyan S. Antibacterial polymeric micelles based on kojic acid/acrylic acid/chitosan. International Journal of Polymeric Materials and Polymeric Biomaterials. 2024;73(2):131 [Crossref]
7- Alami-Milani M, Zakeri-Milani P, Valizadeh H, Fathi M, Salatin S, Salehi R, Jelvehgari M. PLA–PCL–PEG–PCL–PLA based micelles for improving the ocular permeability of dexamethasone: development, characterization, and in vitro evaluation. Pharmaceutical Development and Technology. 2020;25(6):704 [Crossref]
8- Chen Y, Chen X, Chen Y, Wei H, Lin S, Tian H, Lin T, Zhao J, Gu X, Crispi S. Preparation, characterisation, and controlled release of sex pheromone-loaded MPEG-PCL diblock copolymer micelles for Spodoptera litura (Lepidoptera: Noctuidae). PLoS ONE. 2018;13(9):e0203062 [Crossref]
9- Mohammadi G, Mirzaeei S, Taghe S, Mohammadi P. Preparation and Evaluation of Eudragit® L100 Nanoparticles LoadedImpregnated with KT Tromethamine Loaded PVA -HEC Insertions forOphthalmic Drug Delivery. Adv Pharm Bull. 2019;9(4):593 [Crossref]
10- Pu X, Zhao L, Li J, Song R, Wang Y, Yu K, Hou X, Qiao P, Zong L, Chang S. A polymeric micelle with an endosomal pH-sensitivity for intracellular delivery and enhanced antitumor efficacy of hydroxycamptothecin. Acta Biomaterialia. 2019;88:357 [Crossref]
11- Jalilzadeh N, Samadi N, Salehi R, Dehghan G, Iranshahi M, Dadpour M, Hamishehkar H. Novel nano-vehicle for delivery and efficiency of anticancer auraptene against colon cancer cells. Sci Rep. 2020;10(1) [Crossref]
12- Saadat M, Mostafaei F, Mahdinloo S, Abdi M, Zahednezhad F, Zakeri-Milani P, Valizadeh H. Drug delivery of pH-Sensitive nanoparticles into the liver cancer cells. Journal of Drug Delivery Science and Technology. 2021;63:102557 [Crossref]
13- Su J, Ma J, Mo F, Yang X, Zhang P, Zhang J. Thermosensitive hydrogels as a controlled release system for alkannin to improve localized treatment of Candida vaginitis after external beam radiotherapy in vitro and in vivo . 2019;77(4) [Crossref]
14- Zhu M, Wang J, Li N. A novel thermo-sensitive hydrogel-based on poly(N-isopropylacrylamide)/hyaluronic acid of ketoconazole for ophthalmic delivery. Artificial Cells, Nanomedicine, and Biotechnology. 2018;46(6):1282 [Crossref]
15- Moghimipour E, Farsimadan N, Salimi A. Ocular Delivery of Quercetin Using Microemulsion System: Design, Characterization, and Ex-vivo Transcorneal Permeation. Iran J Pharm Res. 2022;21(1) [Crossref]
16- Salatin S, Barar J, Barzegar-Jalali M, Adibkia K, Jelvehgari M. Thermosensitive in situ nanocomposite of rivastigmine hydrogen tartrate as an intranasal delivery system: Development, characterization, ex vivo permeation and cellular studies. Colloids and Surfaces B: Biointerfaces. 2017;159:629 [Crossref]
17- Elfaky M, Sirwi A, Tolba H, Shaik R, Selmi N, Alattas A, Albreki R, Alshreef N, Gad H. Development, Optimization, and Antifungal Assessment of Ocular Gel Loaded With Ketoconazole Cubic Liquid Crystalline Nanoparticles. Journal of Pharmaceutical Sciences. 2021;110(5):2210 [Crossref]
18- Pirpour Tazehkand A, Salehi R, Velaei K, Samadi N. The potential impact of trigonelline loaded micelles on Nrf2 suppression to overcome oxaliplatin resistance in colon cancer cells. Mol Biol Rep. 2020;47(8):5817 [Crossref]
19- Wu Y, Tao Q, Xie J, Lu L, Xie X, Zhang Y, Jin Y. Advances in Nanogels for Topical Drug Delivery in Ocular Diseases. Gels. 2023;9(4):292 [Crossref]
20- Trofimiuk M, Wasilewska K, Winnicka K. How to Modify Drug Release in Paediatric Dosage Forms? Novel Technologies and Modern Approaches with Regard to Children’s Population. IJMS. 2019;20(13):3200 [Crossref]
21- Allyn M, Luo R, Hellwarth E, Swindle-Reilly K. Considerations for Polymers Used in Ocular Drug Delivery. Front Med. 2022;8 [Crossref]
22- Smith S, Abbaraju S, Salmon J, Amin R, Weiss S, Grau U, Velagaleti P, Gilger B. Evaluation of pentablock co-polymer (PTS sol ) for sustained topical ocular drug delivery. Journal of Drug Delivery Science and Technology. 2017;39:475 [Crossref]
23- Romanovska A, Schmidt M, Brandt V, Tophoven J, Tiller J. Controlling the function of bioactive worm micelles by enzyme-cleavable non-covalent inter-assembly cross-linking. Journal of Controlled Release. 2024;368:15 [Crossref]
24- Negut I, Bita B. Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery. Pharmaceutics. 2023;15(3):976 [Crossref]
25- Pouya F, Salehi R, Rasmi Y, Kheradmand F, Fathi-Azarbayjani A. Combination chemotherapy against colorectal cancer cells: Co-delivery of capecitabine and pioglitazone hydrochloride by polycaprolactone-polyethylene glycol carriers. Life Sciences. 2023;332:122083 [Crossref]
26- Taurin S, Almomen A, Pollak T, Kim S, Maxwell J, Peterson C, Owen S, Janát-Amsbury M. Thermosensitive hydrogels a versatile concept adapted to vaginal drug delivery. Journal of Drug Targeting. 2018;26(7):533 [Crossref]
27- Wen Y, Ban J, Mo Z, Zhang Y, An P, Liu L, Xie Q, Du Y, Xie B, Zhan X, Tan L, Chen Y, Lu Z. A potential nanoparticle-loaded in situ gel for enhanced and sustained ophthalmic delivery of dexamethasone. Nanotechnology. 2018;29(42):425101 [Crossref]