Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail

Abed Ghavami ¹, Neda Roshanravan ², Shahriar Alipour ³, Meisam Barati ⁴, Behzad Mansoori ⁵, Faezeh Ghalichi ¹, Elyas Nattagh- Eshtivan ¹, Alireza Ostadrahimi ⁶ *

Cited by CrossRef: 18

1- Zhang W, Tang Y, Huang J, Yang Y, Yang Q, Hu H. Efficacy of inulin supplementation in improving insulin control, HbA1c and HOMA-IR in patients with type 2 diabetes: a systematic review and meta-analysis of randomized controlled trials. J Clin Biochem Nutr. 2020;66(3):176 [Crossref]

2- Qin Y, Wang L, Yang X, Xu Y, Fan G, Fan Y, Ren J, An Q, Li X. Inulin: properties and health benefits. Food Funct. 2023;14(7):2948 [Crossref]

3- Li L, Li P, Xu L. Assessing the effects of inulin‐type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta‐analysis of randomized controlled trials. Food Science & Nutrition. 2021;9(8):4598 [Crossref]

4- Rao M, Gao C, Xu L, Jiang L, Zhu J, Chen G, Law B, Xu Y. Effect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis. Journal of Diabetes Research. 2019;2019:1 [Crossref]

5- Faghihimani Z, Namazi N, Ghaffari S, Rezaei Kelishadi M, Sharifi S, Nattagh-Eshtivani E, Akbarzadeh M, Moravejolahkami A, Khorvash F, Roshanravan N, Alamdari N. Effects of Inulin Type-Carbohydrates on blood pressure: a systematic review and meta-analysis. International Journal of Food Properties. 2021;24(1):129 [Crossref]

6- Chakraborty P, Gamage H, Laird A. Butyrate as a potential therapeutic agent for neurodegenerative disorders. Neurochemistry International. 2024;176:105745 [Crossref]

7- Ghaffari S, Roshanravan N. The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature. Food Research International. 2020;128:108749 [Crossref]

8- Wang L, Yang H, Huang H, Zhang C, Zuo H, Xu P, Niu Y, Wu S. Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose–response meta-analysis of 33 randomized controlled trials. J Transl Med. 2019;17(1) [Crossref]

9- Jayedi A, Aletaha A, Zeraattalab-Motlagh S, Shahinfar H, Mohammadpour S, Mirrafiei A, Jibril A, Soltani A, Shab-Bidar S. Comparative efficacy and safety of probiotics, prebiotics, and synbiotics for type 2 diabetes management: A systematic review and network meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2024;18(1):102923 [Crossref]

10- Mitchell C, Davy B, Ponder M, McMillan R, Hughes M, Hulver M, Neilson A, Davy K. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients. 2021;13(9):3235 [Crossref]

11- Juhász A, Greff D, Teutsch B, Gede N, Hegyi P, Horváth E, Deák P, Nyirády P, Ács N, Juhász R. Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: a systematic review and network meta-analysis. The American Journal of Clinical Nutrition. 2023;117(2):266 [Crossref]

12- Thibonnier M, Ghosh S, Blanchard A. Effects of a short‐term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects. J Cellular Molecular Medi. 2022;26(2):548 [Crossref]

13- Farrim M, Gomes A, Milenkovic D, Menezes R. Gene expression analysis reveals diabetes-related gene signatures. Hum Genomics. 2024;18(1) [Crossref]

14- Wang X, Yan C, Liu J. Hyperinsulinemia-induced KLF5 mediates endothelial angiogenic dysfunction in diabetic endothelial cells. J Mol Hist. 2019;50(3):239 [Crossref]

15- Manning P, Munasinghe P, Bellae Papannarao J, Gray A, Sutherland W, Katare R. Acute Weight Loss Restores Dysregulated Circulating MicroRNAs in Individuals Who Are Obese. 2019;104(4):1239 [Crossref]

16- Xie Y, Gou L, Peng M, Zheng J, Chen L. Effects of soluble fiber supplementation on glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition. 2021;40(4):1800 [Crossref]

17- Li J, Liu L, Zhou W, Cai L, Xu Z, Rane M. Roles of Krüppel‐like factor 5 in kidney disease. J Cellular Molecular Medi. 2021;25(5):2342 [Crossref]

18- Tawfick M, Xie H, Zhao C, Shao P, Farag M. Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics. International Journal of Biological Macromolecules. 2022;208:948 [Crossref]

19- Musazadeh V, Roshanravan N, Dehghan P, Ahrabi S. Effect of Probiotics on Liver Enzymes in Patients With Non-alcoholic Fatty Liver Disease: An Umbrella of Systematic Review and Meta-Analysis. Front Nutr. 2022;9 [Crossref]

20- Roshanravan N, Askari S, Fazelian S, Ayati M, Namazi N. The roles of quercetin in diabetes mellitus and related metabolic disorders; special focus on the modulation of gut microbiota: A comprehensive review. Critical Reviews in Food Science and Nutrition. 2023;63(17):2990 [Crossref]