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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2019;9(1): 76-83. doi: 10.15171/apb.2019.010
PMID: 31011561        PMCID: PMC6468218

Research Article

Preconditioning of Mesenchymal Stem Cells with Non-ToxicConcentration of Hydrogen Peroxide Against Oxidative StressInduced Cell Death: The Role of Hypoxia-Inducible Factor-1

Fatemeh Nouri 1 ORCID, Seyed Noureddin Nematollahi-Mahani 2 ORCID, Ali Mohammad Sharifi 3 * ORCID

Cited by CrossRef: 25

1- Albaqami M, Aguida B, Pourmostafa A, Ahmad M, Kishore V. Photobiomodulation effects of blue light on osteogenesis are induced by reactive oxygen species. Lasers Med Sci. 2023;39(1) [Crossref]
2- Zan Y, Dai Z, Liang L, Deng Y, Dong L. Co-delivery of plantamajoside and sorafenib by a multi-functional nanoparticle to combat the drug resistance of hepatocellular carcinoma through reprograming the tumor hypoxic microenvironment. Drug Delivery. 2019;26(1):1080 [Crossref]
3- Pokholenko I, Pikus P, Kovalchuk M, Toporova O, Rymar S, Kordium V. Effects of transplantation of preconditioned mesenchymal stem cells seeded on a biomimetic 3D scaffold. Biopolym Cell. 2023;39(3):209 [Crossref]
4- Suryawan I, Pikir B, Rantam F, Ratri A, Nugraha R. Hypoxic preconditioning promotes survival of human adipose derived mesenchymal stem cell via expression of prosurvival and proangiogenic biomarkers. F1000Res. 2024;10:843 [Crossref]
5- Abdolmohammadi K, Mahmoudi T, Nojehdehi S, Tayebi L, Hashemi S, Noorbakhsh F, Abdollahi A, Soleimani M, Nikbin B, Nicknam M. Effect of Hypoxia Preconditioned Adipose-Derived Mesenchymal Stem Cell Conditioned Medium on Cerulein-Induced Acute Pancreatitis in Mice. Adv Pharm Bull. 2020;10(2):297 [Crossref]
6- Guo L, Du J, Yuan D, Zhang Y, Zhang S, Zhang H, Mi J, Ning Y, Chen M, Wen D, Sun J, Liu D, Zeng L, Zhang A, Jiang J, Huang H. Optimal H2O2 preconditioning to improve bone marrow mesenchymal stem cells’ engraftment in wound healing. Stem Cell Res Ther. 2020;11(1) [Crossref]
7- Sheppard A, Barfield A, Barton S, Dong Y. Understanding Reactive Oxygen Species in Bone Regeneration: A Glance at Potential Therapeutics and Bioengineering Applications. Front Bioeng Biotechnol. 2022;10 [Crossref]
8- Kovalchuk M, Shuvalova N, Kordium V. Peculiarities of the metabolic activity of mesenchimal stem cells under oxidative stress. Fakt eksp evol org. 2020;26:212 [Crossref]
9- Li X, Zou Y, Xing J, Fu Y, Wang K, Wan P, Zhai X. Pretreatment with Roxadustat (FG-4592) Attenuates Folic Acid-Induced Kidney Injury through Antiferroptosis via Akt/GSK-3β/Nrf2 Pathway. Oxidative Medicine and Cellular Longevity. 2020;2020:1 [Crossref]
10- Chatzimentor I, Tsamesidis I, Ioannou M, Pouroutzidou G, Beketova A, Giourieva V, Papi R, Kontonasaki E. Study of Biological Behavior and Antimicrobial Properties of Cerium Oxide Nanoparticles. Pharmaceutics. 2023;15(10):2509 [Crossref]
11- Puig-Pijuan T, de Godoy M, Pinheiro Carvalho L, Bodart-Santos V, Lindoso R, Pimentel-Coelho P, Mendez-Otero R. Human Wharton’s Jelly Mesenchymal Stem Cells Protect Neural Cells from Oxidative Stress Through Paracrine Mechanisms. Future Sci OA. 2020;6(9) [Crossref]
12- Kovalchuk M, Shuvalova N, Kordium V. Donor variability of the Wharton`s jelly-derived MSCs in response to oxidative stress. Biopolym Cell. 2022;37(6):419 [Crossref]
13- Jiang E, Wang K, Zhang Q, Cui Z, Jiang Z, Gao S, Chen J. H₂O₂ preconditioning enhances the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells after traumatic brain injury. International Immunopharmacology. 2025;161:115018 [Crossref]
14- Wang X, Wei L, Li Q, Lai Y. HIF-1α protects osteoblasts from ROS-induced apoptosis. Free Radical Research. 2022;56(2):143 [Crossref]
15- Suryawan I, Pikir B, Rantam F, Ratri A, Nugraha R. Hypoxic preconditioning promotes survival of human adipose derived mesenchymal stem cell via expression of prosurvival and proangiogenic biomarkers. F1000Res. 2022;10:843 [Crossref]
16- Wong J, Mehta A, Vũ T, Yeo G. Cellular modifications and biomaterial design to improve mesenchymal stem cell transplantation. Biomater Sci. 2023;11(14):4752 [Crossref]
17- Graceffa V. Therapeutic Potential of Reactive Oxygen Species: State of the Art and Recent Advances. SLAS Technology. 2021;26(2):140 [Crossref]
18- Wasnik K, Gupta P, Singh G, Maity S, Patra S, Pareek D, Kumar S, Rai V, Prakash R, Acharya A, Maiti P, Mukherjee S, Mastai Y, Paik P. Neurogenic and angiogenic poly(N-acryloylglycine)-co-(acrylamide)-co-(N-acryloyl-glutamate) hydrogel: preconditioning effect under oxidative stress and use in neuroregeneration. J Mater Chem B. 2024;12(25):6221 [Crossref]
19- Moeinabadi-Bidgoli K, Babajani A, Yazdanpanah G, Farhadihosseinabadi B, Jamshidi E, Bahrami S, Niknejad H. Translational insights into stem cell preconditioning: From molecular mechanisms to preclinical applications. Biomedicine & Pharmacotherapy. 2021;142:112026 [Crossref]
20- Mahmoudi T, Abdolmohammadi K, Bashiri H, Mohammadi M, Rezaie M, Fathi F, Fakhari S, Rezaee M, Jalili A, Rahmani M, Tayebi L. Hydrogen Peroxide Preconditioning Promotes Protective Effects of Umbilical Cord Vein Mesenchymal Stem Cells in Experimental Pulmonary Fibrosis. Adv Pharm Bull. 2019;10(1):72 [Crossref]
21- Yoon H, Cho S, Kim H, Lee J. Protective Effects of Changbudodam-tang on Cell Death Signals on the Bone Marrow-Derived Human Mesenchymal Stem Cells via Regulation of MKK7/JNK/c-Jun Signaling Pathway. J Pharmacopuncture. 2024;27(2):131 [Crossref]
22- Suryawan I, Pikir B, Rantam F, Ratri A, Nugraha R. Hypoxic Preconditioning Promotes Survival of Human Adipose Derived Mesenchymal Stem Cell. F1000Res. 2024;10:843 [Crossref]
23- Suryawan I, Pikir B, Rantam F, Ratri A, Nugraha R. Hypoxic preconditioning promotes survival of human adipocyte mesenchymal stem cell via expression of prosurvival and proangiogenic biomarkers. F1000Res. 2021;10:843 [Crossref]
24- Burón M, Palomares T, Garrido-Pascual P, Herrero de la Parte B, García-Alonso I, Alonso-Varona A. Conditioned Medium from H2O2-Preconditioned Human Adipose-Derived Stem Cells Ameliorates UVB-Induced Damage to Human Dermal Fibroblasts. Antioxidants. 2022;11(10):2011 [Crossref]
25- Tompkins Y, Liu G, Kim W. Impact of exogenous hydrogen peroxide on osteogenic differentiation of broiler chicken compact bones derived mesenchymal stem cells. Front Physiol. 2023;14 [Crossref]
26- Oontawee S, Siriarchavatana P, Rodprasert W, Padeta I, Pamulang Y, Somparn P, Pisitkun T, Nambooppha B, Sthitmatee N, Na Nan D, Osathanon T, Egusa H, Sawangmake C. Small extracellular vesicles derived from sequential stimulation of canine adipose-derived mesenchymal stem cells enhance anti-inflammatory activity. BMC Vet Res. 2025;21(1) [Crossref]