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Adv Pharm Bull. 2020;10(4): 556-565. doi: 10.34172/apb.2020.066
PMID: 33062602        PMCID: PMC7539304

Review Article

Tumor-Associated Macrophages: Protumoral Macrophages in Inflammatory Tumor Microenvironment

Somaiyeh Malekghasemi 1 ORCID, Jafar Majidi 2,3, Amir Baghbanzadeh 1, Jalal Abdolalizadeh 4, Behzad Baradaran 2,3 * ORCID, Leili Aghebati-Maleki 2,3 * ORCID

Cited by CrossRef: 28


1- Cui M, Liu Y, Cheng L, Li T, Deng Y, Liu D. Research progress on anti-ovarian cancer mechanism of miRNA regulating tumor microenvironment. Front Immunol. 2022;13 [Crossref]
2- Zhuang X, Li B, Liu X, Fan T, Lan X, Wang X, Yu M. The colorectal cancer-specific microbiome regulation and immune response activation via an artificial biomimetic nanovaccine. Chemical Engineering Journal. 2023;461:141982 [Crossref]
3- Abdul-Rahman T, Ghosh S, Badar S, Nazir A, Bamigbade G, Aji N, Roy P, kachani H, Garg N, Lawal L, Bliss Z, Wireko A, Atallah O, Adebusoye F, Teslyk T, Sikora K, Horbas V. The paradoxical role of cytokines and chemokines at the tumor microenvironment: a comprehensive review. Eur J Med Res. 2024;29(1) [Crossref]
4- Aggarwal A, Khalighi S, Babu D, Li H, Azarianpour-Esfahani S, Corredor G, Fu P, Mokhtari M, Pathak T, Thayer E, Modesitt S, Mahdi H, Avril S, Madabhushi A. Computational pathology identifies immune-mediated collagen disruption to predict clinical outcomes in gynecologic malignancies. Commun Med. 2024;4(1) [Crossref]
5- Wang S, Kuai Y, Lin S, Li L, Gu Q, Zhang X, Li X, He Y, Chen S, Xia X, Ruan Z, Lin C, Ding Y, Zhang Q, Qi C, Li J, He X, Pathak J, Zhou W, Liu S, Wang L, Zheng L. NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer. BMC Med. 2023;21(1) [Crossref]
6- Benaiges E, Ceperuelo-Mallafré V, Madeira A, Bosch R, Núñez-Roa C, Ejarque M, Maymó-Masip E, Huber-Ruano I, Lejeune M, Vendrell J, Fernández-Veledo S. Survivin drives tumor-associated macrophage reprogramming: a novel mechanism with potential impact for obesity. Cell Oncol. 2021;44(4):777 [Crossref]
7- Qiu X, Zhao T, Luo R, Qiu R, Li Z. Tumor-Associated Macrophages: Key Players in Triple-Negative Breast Cancer. Front Oncol. 2022;12 [Crossref]
8- Umakoshi M, Nakamura A, Tsuchie H, Li Z, Kudo-Asabe Y, Miyabe K, Ito Y, Yoshida M, Nagasawa H, Okada K, Nanjo H, Maeda D, Miyakoshi N, Tanaka M, Goto A. Macrophage numbers in the marginal area of sarcomas predict clinical prognosis. Sci Rep. 2023;13(1) [Crossref]
9- Xing Y, Ruan G, Ni H, Qin H, Chen S, Gu X, Shang J, Zhou Y, Tao X, Zheng L. Tumor Immune Microenvironment and Its Related miRNAs in Tumor Progression. Front Immunol. 2021;12 [Crossref]
10- Vakhshiteh F, Bagheri Z, Soleimani M, Ahvaraki A, Pournemat P, Alavi S, Madjd Z. Heterotypic tumor spheroids: a platform for nanomedicine evaluation. J Nanobiotechnol. 2023;21(1) [Crossref]
11- da Costa V, Freire T. Advances in the Immunomodulatory Properties of Glycoantigens in Cancer. Cancers. 2022;14(8):1854 [Crossref]
12- Li F, Zheng X, Wang X, Xu J, Zhang Q. Macrophage polarization synergizes with oxaliplatin in lung cancer immunotherapy via enhanced tumor cell phagocytosis. Translational Oncology. 2021;14(11):101202 [Crossref]
13- Liu X, Yin L, Shen S, Hou Y. Inflammation and cancer: paradoxical roles in tumorigenesis and implications in immunotherapies. Genes & Diseases. 2023;10(1):151 [Crossref]
14- Ferdosnejad K, Zamani M, Soroush E, Fateh A, Siadat S, Tarashi S. Tuberculosis and lung cancer: metabolic pathways play a key role. Nucleosides, Nucleotides & Nucleic Acids. 2024;:1 [Crossref]
15- De Gregorio A, Krasnowska E, Zonfrillo M, Ravagnan G, Bordignon V, Bonmassar E, Fuggetta M. Influence of Polydatin on the Tumor Microenvironment In Vitro: Studies with a Colon Cancer Cell Model. IJMS. 2022;23(15):8442 [Crossref]
16- Wang Z, Ning Z, Ma C, Liu T, Tao B, Guo L. Low expression of lysosome-related genes KCNE1, NPC2, and SFTPD promote cancer cell proliferation and tumor associated M2 macrophage polarization in lung adenocarcinoma. Heliyon. 2024;10(6):e27575 [Crossref]
17- Duan S, Wang S, Huang T, Wang J, Yuan X. circRNAs: Insight Into Their Role in Tumor-Associated Macrophages. Front Oncol. 2021;11 [Crossref]
18- Decollogny M, Rottenberg S. Persisting cancer cells are different from bacterial persisters. Trends in Cancer. 2024; [Crossref]
19- Brindisi M, Frattaruolo L, Fiorillo M, Dolce V, Sotgia F, Lisanti M, Cappello A. New insights into cholesterol‐mediated ERRα activation in breast cancer progression and pro‐tumoral microenvironment orchestration. The FEBS Journal. 2023;290(6):1481 [Crossref]
20- Ahmad R, Eubank T, Lukomski S, Boone B. Immune Cell Modulation of the Extracellular Matrix Contributes to the Pathogenesis of Pancreatic Cancer. Biomolecules. 2021;11(6):901 [Crossref]
21- Wang X, Wei S, Li W, Wei X, Zhang C, Dai S, Ma M, Zhao L, Shan B. P-Hydroxylcinnamaldehyde induces tumor-associated macrophage polarization toward the M1 type by regulating the proteome and inhibits ESCC in vivo and in vitro. International Immunopharmacology. 2023;119:110213 [Crossref]
22- Dudzinski S, Bader J, Beckermann K, Young K, Hongo R, Madden M, Abraham A, Reinfeld B, Ye X, MacIver N, Giorgio T, Rathmell J. Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages. 2021;207(12):3122 [Crossref]
23- Wang X, Li X, Wang X. Identification of immune microenvironment subtypes that predicted the prognosis of patients with ovarian cancer. J Cellular Molecular Medi. 2021;25(8):4053 [Crossref]
24- Bai J, Zhang X, Meng W, Xu H, Liu Y, Zhong Y, Lin X, Wang J, fan D, Lv G, Gu Y. Dioscin decreases M2 polarization via inhibiting a positive feedback loop between RBM47 and NF-κB in glioma. Phytomedicine. 2024;128:155417 [Crossref]
25- Wang H, Tian T, Zhang J. Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis. IJMS. 2021;22(16):8470 [Crossref]
26- Choi Y, Lee D, Kim N, Seo I, Park N, Chong G. Role of Tumor-Associated Macrophages in Cervical Cancer: Integrating Classical Perspectives with Recent Technological Advances. Life. 2024;14(4):443 [Crossref]
27- Gluba-Brzózka A, Rysz J, Ławiński J, Franczyk B. Renal Cell Cancer and Obesity. IJMS. 2022;23(6):3404 [Crossref]
28- Raj A, Babu A, Kothandan V, Park I, Hwang S. Development of nano-immunotherapy for cancer treatment: achievements and scopes. J Pharm Investig. 2023;53(6):827 [Crossref]
29- Deng Z, Qishan S, Zhang Q, Wang J, Yue Y, Geng L, Wu N. Low molecular weight fucoidan LF2 improves the immunosuppressive tumor microenvironment and enhances the anti-pancreatic cancer activity of oxaliplatin. Biomedicine & Pharmacotherapy. 2024;173:116360 [Crossref]
30- Travers J, Rohan J, Sahu R. New Insights Into the Pathologic Roles of the Platelet-Activating Factor System. Front Endocrinol. 2021;12 [Crossref]
31- Li C, Xu Y, Zhang J, Zhang Y, He W, Ju J, Wu Y, Wang Y. The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice. Sci Rep. 2023;13(1) [Crossref]
32- Matsuo K, Yoshie O, Nakayama T. Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity. Cancers. 2021;13(23):6132 [Crossref]
33- Sampaio-Ribeiro G, Ruivo A, Silva A, Santos A, Oliveira R, Gama J, Cipriano M, Tralhão J, Paiva A. Innate Immune Cells in the Tumor Microenvironment of Liver Metastasis from Colorectal Cancer: Contribution to a Comprehensive Therapy. Cancers. 2023;15(12):3222 [Crossref]
34- Hu M, Fan J, He Z, Zeng J. The regulatory role of autophagy between TAMs and tumor cells. Cell Biochemistry & Function. 2024;42(2) [Crossref]
35- Guo J, Wang M, Zhu Y, Watari F, Xu Y, Chen X. Exploitation of platelets for antitumor drug delivery and modulation of the tumor immune microenvironment. 2023;2(2) [Crossref]
36- Zhang H, Li Y. Targeting the breast tumor microenvironment by plant-derived products and their nanoformulations. Journal of Drug Delivery Science and Technology. 2024;93:105432 [Crossref]
37- Satish M, Ayyathurai M, Mahadevan S, Ramadas M. Tumor Microenvironment and its Role in Metastasis. JRAD. 2022;14(1):28 [Crossref]