Adv Pharm Bull. 2015;5(3):305-313.
doi: 10.15171/apb.2015.043
PMID: 26504751
PMCID: PMC4616893
Scopus id: 84983573851
  Abstract View: 2212
  PDF Download: 2993

Review Article

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers: Structure, Preparation and Application

Neda Naseri 1, Hadi Valizadeh 2, Parvin Zakeri-Milani 3 *

1 Student Research Committee and Faculty of Advanced Medical Sciences, Department of Medical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Liver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.


Lipid nanoparticles (LNPs) have attracted special interest during last few decades. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are two major types of Lipid-based nanoparticles. SLNs were developed to overcome the limitations of other colloidal carriers, such as emulsions, liposomes and polymeric nanoparticles because they have advantages like good release profile and targeted drug delivery with excellent physical stability. In the next generation of the lipid nanoparticle, NLCs are modified SLNs which improve the stability and capacity loading. Three structural models of NLCs have been proposed. These LNPs have potential applications in drug delivery field, research, cosmetics, clinical medicine, etc. This article focuses on features, structure and innovation of LNPs and presents a wide discussion about preparation methods, advantages, disadvantages and applications of LNPs by focusing on SLNs and NLCs.
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Submitted: 15 May 2015
Revised: 15 Jun 2015
First published online: 19 Sep 2015
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