Mahshid Saleh
1, karim Shamsasanjan
1,2*, Aliakbar Movassaghpourakbari
1, Parvin Akbarzadehlaleh
3, Zahra Molaeipour
11 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
3 Department of Pharmaceutical Biotechnology, Tabriz University of Medical Science, Tabriz, Iran.
Abstract
Bone marrow microenvironment contains cellular and
acellular compartments. The cellular compartment includes hematopoietic stem
cells, mesenchymal stem cells and some other stromal cell types, while the
acellular compartment is composed of scaffold proteins known as the extra
cellular matrix. Direct cell-cell contact as well as cytokines secreted by
mesenchymal stem cells during coculture of hematopoietic stem cells and
mesenchymal stem cells play a critical role in hematopoiesis, and determines
the fate of hematopoietic stem cells. Several studies have demonstrated the
impact of mesenchymal stem cells on self-renewal, expansion, proliferation and differentiation
of hematopoietic stem cells in vitro, which have shown different and
contradictory results. In this paper, we will investigate the effect of
mesenchymal stem cells on differentiation of hematopoietic stem cells in vitro.