Adv Pharm Bull. 2018;8(3):355-363.
doi: 10.15171/apb.2018.042
  Abstract View: 394
  PDF Download: 468

Review Article

A Review about Regulatory Status and Recent Patents of Pharmaceutical Co-Crystals

Arun Kumar 1 ORCiD, Sandeep Kumar 1 ORCiD, Arun Nanda 1 * ORCiD

1 Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India.

Abstract

Pharmaceutical Co-crystals are not new, they have gained much attention since the last decade among scientists and pharmaceutical industry. Pharmaceutical co-crystals are multicomponent systems composed of two or more molecules and held together by non-covalent interactions. The development of pharmaceutical co-crystals, a new solid crystalline form, offer superior physico-chemical properties (such as melting point, stability, solubility, permeability, bioavailability, taste masking, etc.) without altering the pharmacological properties. Recently, with the upsurge in the growth of Pharmaceutical co-crystals, the major concern is over the regulatory status of co-crystals. With the new guidelines from United States Food and Drug Administration (USFDA) and European Medicines Agency (EMA), the status has become even more complicated due to significantly different opinions. This review highlights whether co-crystals fulfil the requirements for the grant of a patent or not and how cocrystals are going to affect the present scenario of pharmaceuticals.
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Submitted: 27 Feb 2018
Revised: 24 Apr 2018
Accepted: 20 May 2018
First published online: 29 Aug 2018
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