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  Abstract View: 46

Review Article

Breast Cancer: a Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development

Gul-e-Saba Chaudhry* ORCID logo

Abstract

Cancer is a complex multifactorial process, unchecked and abrupt division, and cell growth—conventional chemotherapy, along with radiotherapy, is used to treat breast cancer. Due to reduce efficacy and less survival rate, there is a particular need for the discovery of new active anticancer agents. Natural resources such as terrestrial/marine plants or organisms are a promising source for the generation of new therapeutics with improving efficacy. The screening of natural plant extracts and fractions, isolations of phytochemicals, and mechanistic study of those potential compounds play a remarkable role in the development of new therapeutic drugs with increased efficacy. Cancer is a multistage disease with complex signaling cascades. The initial study of screening whole extracts or fractions and later the isolation of secondary compounds and their mechanism of action study gives a clue of potential therapeutic agents for future drug development. The phytochemicals present in extracts/fractions produce remarkable effects due to synergistically targeting multiple signals. In this review, the molecular targets of extracts/ fractions and isolated compounds highlighted. The therapeutic agent's mechanistic targets in drug development focused involves; i) Induction of Apoptosis, ii) modulating cell cycle arrest, iii) Inhibition or suppression of invasion and metastasis and iv) various other pro-survival signaling pathways. The phytochemicals and their modified analogs identified as future potential candidates for anticancer chemotherapy.
Keywords: Apoptosis, Breast cancer, Cell cycle arrest, drug develpoment, Natural products, Mechanism of action, Plant anticancer drugs.
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Submitted: 27 Feb 2020
Revision: 10 Aug 2020
Accepted: 14 Oct 2020
ePublished: 14 Oct 2020
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