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Adv Pharm Bull. 2022;12(1): 17-33.
doi: 10.34172/apb.2022.007
PMID: 35517874
PMCID: PMC9012924
Scopus ID: 85127147891
  Abstract View: 1116
  PDF Download: 736
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Review Article

A Recent Update: Solid Lipid Nanoparticles for Effective Drug Delivery

Sonia Pandey 1* ORCID logo, Farhinbanu Shaikh 1, Arti Gupta 1 ORCID logo, Purnima Tripathi 2, Jitendra Singh Yadav 3 ORCID logo

1 Maliba Pharmacy College, Uka tarsadia University, Bardoli Mahuva Road, Surat 394350, Gujarat, India.
2 Department of Pharmaceutics, Bundelkhand University, Jhansi, U.P India.
3 Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umarkh, Surat 394350, Gujarat, India.
*Corresponding Author: Sonia Pandey, Fax: +91 (02625) (255882), Emails: sonia136@rediffmail.com, soniapandeypharm@gmail.com, Email: sonia136@rediffmail.com

Abstract

Solid lipid nanoparticles (SLNs) are one of the developed technologies for addressing thebioavailability and targeting issues of drug delivery. In this review article, we attempted toincorporate all the essential details of SLNs like various methods of preparation, different modelsof SLNs, updated characterization methods, in vivo behavior (uptake), their applications, routeof administration as well as advancements taken place in the field of delivery of biological drugslike gene vector, new adjuvant for vaccines, protein, and peptide with SLNs. Surface modifiedSLNs hold excellent potential for targeted and controlled drug delivery which is discussed andsummarized. Based on the available data, the future success of SLNs is widened because theycould be easily fabricated with various functionalities which would display enormous potentialfor targeting and diagnosing various diseases. This review would help the budding researchers tofind out the unexplored areas of SLNs with the present discussion that reframes the potential ofSLNs by gathering the various research findings of SLNs in tabular form along with the approvedpatent technologies of SLNs.
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Submitted: 19 Mar 2020
Revision: 31 Mar 2021
Accepted: 14 May 2021
ePublished: 16 May 2021
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