Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications

Abstract

Transdermal delivery over the past decade has become the field of interest for drug deliverydue to its various advantages such as no first-pass metabolism, increased drug bioavailability,and easy administration. Different vesicle systems like ethosomes, liposomes, niosomes, andtransferosomes along with particle systems like lipid nanoparticles, polymeric nanoparticles,carbon nanotubes, and fullerenes have been developed. These vesicles and particle systemshave been developed using various easy and effective methods like cold injection method,rotary film evaporation, thin film hydration, high shear homogenization, solvent extractionmethod, and many more. These drug delivery systems are a very effective and feasible optionfor transdermal drug delivery and further developments can be made to increase their use.This article explains in detail the preparation methods and applications for these drug deliverysystems.

Keywords: Transdermal, Dermal, Vesicle systems, Particle systems, Niosomes, Ethosomes, Nanoparticles, Transferosomes, Drug delivery