Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 9 1 2019 02 21 Cancer Cells Treated by Clusters of Copper Oxide Doped Calcium Silicate 102 109 10.15171/apb.2019.013 EN Mostafa Mabrouk https://orcid.org/0000-0003-3330-6762 Sayed Hamed Kenawy https://orcid.org/0000-0002-0974-4837 Gehan El Tabie El-Bassyouni https://orcid.org/0000-0001-8438-0570 Ahmed Abd El-Fattah Ibrahim Soliman https://orcid.org/0000-0002-5046-8088 Esmat Mahmoud Aly Hamzawy https://orcid.org/0000-0002-0984-9911 Journal Article 10.15171/apb.2019.013 2018 05 13 2018 11 12 Purpose: Different compositions of copper oxide (CuO)-doped calcium silicate clusters wereused to treat the cancer cells.Methods: The influence of CuO content on the morphology, drug delivering ability,physicochemical properties and cytotoxicity was investigated.Results: The microcrystalline structure revealed the decrement of the size from (20-36 nm) to(5-7 nm) depending on the copper content percentages. Drug delivering ability of doxycyclinehyclate (Dox) was down regulated from 58% to 28%in the presence of the CuO. The inclusionof CuO and Dox didn’t show any remarkable changes on the physicochemical properties of theCuO-doped calcium silicate nanoparticles.Conclusion: The CuO-doped calcium silicate sample (5 weight %) exhibited great cytotoxicityagainst the tested cell lines compared to the CuO-free sample. CuO-doped materials displayedsignificant anticancer effect; this sheds light on its implication in the treatment of cancer.