Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 4 6 2014 12 30 Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages 479 481 10.5681/apb.2014.071 EN Sheida Shaafi Javad Mahmoudi Ali Pashapour Mehdi Farhoudi Saeed Sadigh-eteghad Hossein Akbari EDITORIAL 10.5681/apb.2014.071 2014 05 27 Ischemic stroke is a leading cause of death and disability in the world. Many mechanisms contribute in cell death in ischemic stroke. Ketogenic diet which has been successfully used in the drug-resistant epilepsy has been shown to be effective in many other neurologic disorders. The mechanisms underlying of its effects are not well studied, but it seems that its neuroprotective ability is mediated at least through alleviation of excitotoxicity, oxidative stress and apoptosis events. On the basis of these mechanisms, it is postulated that ketogenic diet could provide benefits to treatment of cerebral ischemic injuries.