Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 9 1 2019 02 21 Testosterone May Hold Therapeutic Promise for the Treatment ofIschemic Stroke in Aging: A Closer Look at Laboratory Findings 48 55 10.15171/apb.2019.006 EN Fereshteh Farajdokht https://orcid.org/0000-0001-5349-6028 Mehdi Farhoudi https://orcid.org/0000-0002-4972-9316 Alireza Majdi https://orcid.org/0000-0002-2990-4762 Masumeh Zamanlu https://orcid.org/0000-0002-6326-8448 Saeed Sadigh-Eteghad https://orcid.org/0000-0003-2872-1072 Shabnam Vahedi https://orcid.org/0000-0003-4087-9630 Javad Mahmoudi https://orcid.org/0000-0003-0589-9812 REVIEW 10.15171/apb.2019.006 2018 04 21 2018 12 22 Male sex is more prone to cerebrovascular disorders, yet the exact role of androgens in cerebralischemia remains unclear. Here we reviewed current understanding of testosterone (TES)neuroprotective activity against ischemic stroke and mechanisms underlying these effects inaging. TES may exert a neuroprotective effect in aging through pathways including inhibition ofoxidant molecules production, enhancing the enzymatic antioxidant capacity of the brain andmodulation of apoptotic cell death. Given this, a better understanding of the neuroprotectiveroles of TES may propose an effective therapeutic strategy to improve the quality of life anddecrease androgen-related cerebrovascular problems in the aging men.