Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 10 4 2020 08 09 Impact of Tablet Shape on Drug Dissolution Rate Through Immediate Released Tablets 656 661 10.34172/apb.2020.079 EN Fatima Molavi https://orcid.org/0000-0003-4829-2009 Hamed Hamishehkar https://orcid.org/0000-0001-9905-0662 Ali Nokhodchi https://orcid.org/0000-0002-3244-2482 Journal Article 10.34172/apb.2020.079 2019 04 09 2020 01 23 Purpose: The aim of this study was to evaluate the influence of the geometric shape on the dissolution rate of the domperidone, a drug model for immediate release dosage form. In this regard, a lack of sufficient information about the effective dissolution rate of the drugs regarding their shapes has made this issue an interesting subject for researchers. Methods: For this purpose, three tablet shapes, namely flat and biconvex both in a round and oblong shapes, with different four sizes were modelled for the preparation of domperidone tablet. In vitro dissolution test was accomplished using a USP dissolution apparatus II. The drug dissolution rate was assessed by calculating various dissolution parameters; e.g., dissolution efficiency (DE), mean dissolution rate (MDR), mean dissolution time (MDT), and difference and similarity factors (f1 and f2 ). Results: Regarding the disintegration time, the larger tablets showed a faster disintegration time. When the size of the tablets was smaller, the amount of released drug was significantly decreased. In addition, #9 tablets with a flat or biconvex geometry had obvious effects on the DE values. Generally, biconvex tablets had higher DE percentage than the flat tablets. Conclusion: Noticeable differences in dissolution parameters by considering the different geometric shapes play an important role in the drug release kinetics which makes a significant effect on quick onset of action in oral administration.