Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 10 3 2020 05 11 A Review on Solid Dispersion and Carriers Used Therein for Solubility Enhancement of Poorly Water Soluble Drugs 359 369 10.34172/apb.2020.044 EN Avinash Ramrao Tekade https://orcid.org/0000-0001-8564-1859 Jyoti Narayan Yadav REVIEW 10.34172/apb.2020.044 2019 05 25 2020 01 23 A large number of hydrophilic and hydrophobic carriers in pharmaceutical excipients are available today which are used for formulation of solid dispersions. Depending on nature of carriers the immediate release solid dispersions and/or controlled release solid dispersions can be formulated. Initially crystalline carriers were used which are transformed into amorphous solid dispersions with enhanced properties. The carriers used previously were mostly synthetic one. Recent trend towards the use of natural carriers have replaced the use of synthetic carriers. This review is the overview of various synthetic, natural, semisynthetic, modified natural hydrophilic carriers used for formulation of solid dispersions.