Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 12 1 2022 01 01 A Recent Update: Solid Lipid Nanoparticles for Effective Drug Delivery 17 33 10.34172/apb.2022.007 EN Sonia Pandey https://orcid.org/0000-0001-6661-5823 Farhinbanu Shaikh Arti Gupta https://orcid.org/0000-0002-1831-4441 Purnima Tripathi Jitendra Singh Yadav https://orcid.org/0000-0002-3578-3450 REVIEW 10.34172/apb.2022.007 2020 03 19 2021 05 14 Solid lipid nanoparticles (SLNs) are one of the developed technologies for addressing thebioavailability and targeting issues of drug delivery. In this review article, we attempted toincorporate all the essential details of SLNs like various methods of preparation, different modelsof SLNs, updated characterization methods, in vivo behavior (uptake), their applications, routeof administration as well as advancements taken place in the field of delivery of biological drugslike gene vector, new adjuvant for vaccines, protein, and peptide with SLNs. Surface modifiedSLNs hold excellent potential for targeted and controlled drug delivery which is discussed andsummarized. Based on the available data, the future success of SLNs is widened because theycould be easily fabricated with various functionalities which would display enormous potentialfor targeting and diagnosing various diseases. This review would help the budding researchers tofind out the unexplored areas of SLNs with the present discussion that reframes the potential ofSLNs by gathering the various research findings of SLNs in tabular form along with the approvedpatent technologies of SLNs.