Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 12 4 2022 08 27 Chemotherapeutic Resistance Genes of Breast Cancer Patients - An Overview 649 657 10.34172/apb.2022.048 EN Anagha Kollamparambil Ajith https://orcid.org/0000-0002-8846-0372 Sasikala Subramani https://orcid.org/0000-0002-9779-8156 Agaath Hedina Manickam https://orcid.org/0000-0001-5263-7407 Sivasamy Ramasamy https://orcid.org/0000-0001-6411-5876 REVIEW 10.34172/apb.2022.048 2020 10 19 2021 05 29 Purpose: Cancer is the leading challenge to human health since the dawn of early Egyptianmanuscripts, where they found tumour from fossils in the modernized 20th century. Increasingrate of incidence and death from cancer in the past few years is thought provoking. Among alltype of cancers, breast cancer is very common among women and diverse in character. Drugresistance is the challenging aspect for traditional chemotherapy.Methods: Data was collected from online platform without any time restriction. After screeningand evaluation, 66 articles were considered for this study. This review is a summarized collectionof information from published studies on human genes associated with drug resistance in breastcancer treatment.Results: Analysis of these findings highlights the importance of MAP kinase and ABC genefamilies in creating resistance barriers. Genes involved in cell cycle alteration, apoptosis, andhippo pathway were also linked with drug resistance particularly in breast cancer.Conclusion: The exact mechanism of chemotherapy resistance is still unresolved andunexplained the drug resistance seen in breast cancer patients were multifactorial. Druginduced up regulation or down regulation of genes contributes unusual protein expression andultimately leads to resistance. The ultimate focus of this review is to identify the genes havingpivotal role in chemotherapy resistance in breast cancer.