Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 12 4 2022 08 27 Electrospun Polycaprolactone Nanofibers: Current Research and Applications in Biomedical Application 658 672 10.34172/apb.2022.070 EN Arezo Azari https://orcid.org/0000-0002-8590-6981 Ali Golchin https://orcid.org/0000-0001-8661-5046 Maryam Mahmoodinia Maymand https://orcid.org/0000-0002-6015-9131 Fatemeh Mansouri https://orcid.org/0000-0002-4850-1328 Abdolreza Ardeshirylajimi https://orcid.org/0000-0001-8858-8635 REVIEW 10.34172/apb.2022.070 2021 01 24 2021 09 27 Unique mechanical properties, miscibility potency, and biodegradability are the threeprominent features of polycaprolactone (PCL), making it an attractive biomaterial whichcommonly applied in regenerative medicine and biomedical engineering. Different strategiesdeveloped for fabricating nanofibrous construct, electrospinning is a practical, simple, andefficient technique based on electro-hydrodynamic systems that use an electrified viscousfluid jet drawn by the air toward a collector at a changing electric potential. PCL electrospunbasednanofibrous composites as proper scaffolds are employed in stem cell-related research,particularly in tissue engineering, wound dressing, and systems designed for sending drugs.A compilation of mechanochemical properties and most common biological performance onPCL-based electrospun fibrous structures in biomedical application are included in this study.Therefore, electrospun PCL nanofiber applying has been presented, and after that, currentprogress and prospects have been discussed. Literature reviews revealed that electrospun PCLnanofibrous composites had gained significant attention in regenerative medicine, and thesestructures have shown notable development in mechanobiological properties. This evidence isa crucial success for biomedical strategies, especially in regenerative medicine.