Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 12 4 2022 08 27 Nanostructured Lipid Carriers for Nose to Brain Delivery TargetingCNS: Diversified Role of Liquid Lipids for Synergistic Action 763 771 10.34172/apb.2022.078 EN Avinash Ramrao Tekade https://orcid.org/0000-0001-8564-1859 Pradeep Sadanand Mittha Charushila Sopan Pisal Journal Article 10.34172/apb.2022.078 2021 02 10 2021 09 27 Neurological disorders such as Alzheimer’s disease, Parkinson’s disease, dementia, epilepsy,depression, migraine etc. are affecting more and more elderly people’s day by day. Conventionalroute of administration to treat these diseases has to face a major hindrance that is bloodbrain and blood-cerebrospinal fluid (CSF) barrier to achieve desired concentration of drug atthe site of action for therapeutic effect. Hence, intranasal route of delivery is considered aspromising and alternative route to achieve desired goals. In last four decades, brain targetingstrategies are widely studied and considered having great potential by researchers; especiallyintranasal delivery owing to its benefits. Various nano formulations such as nanoemulsions,nanosuspensions, hydrogels, in situ gels, dendrimers and lipidic formulations are studiedwidely. Lipid nano formulations especially second generation nanostructured lipid carriersoffer greater advantages in terms of stability, fabrication techniques, scalability, drug loadingand drug targeting. Nanostructured lipid carrier (NLCs) constitute of two major componentsviz solid lipid and liquid lipid in a specific ratio. In this review, authors have discussed aboutthe possible synergistic actions of oils/liquid lipids with synthetic drugs resulting into greattherapeutic benefits.