Tabriz University of Medical Sciences Advanced Pharmaceutical Bulletin 2228-5881 14 1 2024 03 07 A Comprehensive Review on Novel Lipid-Based Nano Drug Delivery 34 47 10.34172/apb.2024.012 EN Sonam Suresh Godase https://orcid.org/0000-0002-6457-878X Nilesh Shrikant Kulkarni https://orcid.org/0000-0002-4801-9419 Shashikant Nivrutti Dhole REVIEW 10.34172/apb.2024.012 2022 02 28 2023 10 08 Novel drug delivery system opens the doors towards nano/micro formulation strategies to overcome the challenges associated with the poorly soluble and permeable drugs. Lipid based nanoparticles are widely accepted that includes liposomes, niosomes and micelles which are FDA approved. Such lipid based drug delivery allows delivery for natural phytoconstituents, biopharmaceutical classification system (BCS) class II and class IV drugs are effectively delivered to improve its solubility, permeability and bioavailability. The article provides the recent advances and application of lipid based dosage form for improvement of therapeutic efficacy.