Adv Pharm Bull. 2018;8(1):49-55.
doi: 10.15171/apb.2018.006
PMID: 29670838
PMCID: PMC5896395
Scopus id: 85044086246
  Abstract View: 719
  PDF Download: 716

Research Article

Novel Combination of Silver Nanoparticles and Carbon Nanotubes for Plasmonic Photo Thermal Therapy in Melanoma Cancer Model

Mohammad Ali Behnam 1, Farzin Emami 1, Zahra Sobhani 2 * , Omid Koohi-Hosseinabadi 3, Amir Reza Dehghanian 4, Seyed Mojtaba Zebarjad 5, Mohammad Hadi Moghim 5, Ahmad Oryan 6

1 Nano Opto-Electronic Research Center, Electrical and Electronics Engineering Department, Shiraz University of Technology, Shiraz, Iran
2 Quality Control Department, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
3 Center of Experimental and Comparative Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
4 Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
5 Materials Science and Engineering Department, Engineering School, Shiraz University, Shiraz, Iran.
6 Pathology Department, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.


Purpose: Plasmonic photo thermal therapy (PPTT) is a therapeutic method in which the photon energy is rapidly transformed into heat via a series of radiative and non-radiative phenomena to ablate cancer. Plasmonic NPs, such as silver NPs (Ag NPs), have considerable properties in optical absorbance. Furthermore, good thermal conductivity and cell penetration ability of carbon nanotubes (CNTs) could improve the efficacy of Ag NPs for PPTT. Decoration of the multi-walled carbon nanotubes (MWCNTs) with silver has been developed to enhance thermal conductivity of the MWCNT particles. Methods: The Ag NPs were decorated on the CNTs and the ability of these particles (CNT/Ag NPs) in reduction of melanoma tumor size after PTT was evaluated experimentally. For comparison, the PTT of silver nanorods (Ag NRs) and CNTs were investigated. The melanoma tumor was induced by injection of B16/F10 cell line to the inbred mice. Different NPs were injected into the tumors and then irradiated via laser diode (λ=670 nm, P=500 mW, and I= 3.5 W/cm2) at scheduled time. Results: Monitoring of tumor sizes showed that integration of CNTs with silver could enhance the optical absorption of CNTs and improve tumor destruction in PPTT technique. Conclusion: The CNT/Ag NPs could act as a potent agent in PPTT method in curing solid tumors.
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Submitted: 07 Jan 2018
Revised: 27 Feb 2018
Accepted: 28 Feb 2018
First published online: 28 Feb 2018
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