Jafar Akbari
*, Majid Saeedi, Katayoun Morteza-Semnani, Hamidreza Kelidari, Maryam Lashkari
1 Department of pharmaceutics, Faculty of pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
2 Department of medicinal chemistry, Faculty of pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
3 Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Abstract
Purpose:
Bioadhesive polymers play an important role in biomedical and drug delivery
applications. The aim of this study is to develop a sustained- release tablet
for local application of Cetylpyridinium Chloride (CPC). This delivery system
would supply the drug at an effective level for a long period of time, and
thereby overcome the problem of the short retention time of CPC and could be
used for buccal delivery as a topical anti-infective agent.
Methods: CPC
bioadhesive tablets were directly prepared using 7 mm flat-faced punches on a
hydraulic press. The materials for each tablet were weighted, introduced into
the die and compacted at constant compression pressure. The dissolution tests
were performed to the rotation paddle method and the bioadhesive strength of
the tablets were measured.
Results:
The results showed that as the concentration of polymer increased, the drug
release rate was decreased. Also the type and ratio of polymers altered the
release kinetic of Cetylpyridinium Chloride from investigated tablets. The bioadhesion
strength increased with increasing the concentration of polymer and maximum
bioadhesion strength was observed with HPMC K100M.
Conclusion: The selected
formulation of CPC bioadhesive tablet can be used as a suitable preparation for
continuous release of CPC with appropriate bioadhesion strength.