Maryam Maghsoodi
1*1 Drug Applied Research Center and School of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
Crystallization is often used for manufacturing drug substances.
Advances of crystallization have achieved control over drug identity and
purity, but control over the physical form remains poor. This review discusses
the influence of solvents used in crystallization process on crystal habit and
agglomeration of crystals with potential implication for dissolution. According
to literature it has
been known that habit modification of crystals by use of proper solvents may
enhance the dissolution properties by changing the size, number and the nature of crystal faces exposed to the dissolution medium. Also, the faster dissolution rate of drug
from the agglomerates of crystals compared with the single crystals may be
related to porous structure of the agglomerates and consequently their better
wettability.
It is
concluded from this review that in-depth understanding of role of the solvents
in crystallization process can be applied to engineering of crystal habit or
crystal agglomeration, and predictably dissolution improvement in poorly
soluble drugs.