Fariba Mirzaie Bavil
1, Gisou Mohaddes
2, Hadi Ebrahimi
3, Rana Keyhanmanesh
1, Rafigheh Ghiyasi
4, Mohammad Reza Alipour
1*1 Tuberculosis and Lung Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
Purpose: Hypoxia is a condition of decreased availability of
oxygen. To adapt hypoxia, some changes in blood cells occur in the body.
The aim of this study was to evaluate the effect of ghrelin on different types
of blood cell in normobaric hypoxia situation.
Methods: Thirty-two animals were divided in 4 groups (n=8):
control (C), ghrelin (G), hypoxia (H), and hypoxic animals that received
ghrelin (H+G). Hypoxia (11%) was induced by an Environmental Chamber System GO2
Altitude. Animals in ghrelin groups received a subcutaneous injection of
ghrelin (150 μg/kg/day) for 14 days.
Results: Our results show that ghrelin
significantly (p<0.05) increased RBC and Hct levels, whereas it
significantly (p<0.05) decreased lymphocytes in the blood. RBC, Hct, Hb
concentration, platelet and MCV increased significantly (p<0.05) in hypoxic
conditions but lymphocytes, monocytes and Polymorphonuclears did not show any
significant changes. Platelets had a significant (p<0.05) decrease in
hypoxic conditions and ghrelin administration in hypoxic conditions could
increase lymphocyte levels significantly (p<0.05).
Conclusion: Effect
of ghrelin on blood cells could be related to blood oxygen level. Ghrelin in
normal oxygen conditions increases RBC and Hct levels but decreases
lymphocytes, whereas in hypoxic conditions, ghrelin increases blood
lymphocytes.