Adv Pharm Bull. 2014;4(6): 479-481.
doi: 10.5681/apb.2014.071
PMID: 25671178
PMCID: PMC4312394
Scopus ID: 84921960557
  Abstract View: 1185
  PDF Download: 566


Ketogenic Diet Provides Neuroprotective Effects against Ischemic Stroke Neuronal Damages

Sheida Shaafi, Javad Mahmoudi, Ali Pashapour, Mehdi Farhoudi, Saeed Sadigh-eteghad, Hossein Akbari*

1 Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.


Ischemic stroke is a leading cause of death and disability in the world. Many mechanisms contribute in cell death in ischemic stroke. Ketogenic diet which has been successfully used in the drug-resistant epilepsy has been shown to be effective in many other neurologic disorders. The mechanisms underlying of its effects are not well studied, but it seems that its neuroprotective ability is mediated at least through alleviation of excitotoxicity, oxidative stress and apoptosis events. On the basis of these mechanisms, it is postulated that ketogenic diet could provide benefits to treatment of cerebral ischemic injuries.
Keywords: Stroke, Ketogenic diet, Excitotoxicity, Oxidative stress, Apoptosis
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Submitted: 27 May 2014
Revision: 27 Aug 2014
ePublished: 31 Oct 2014
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