Nasser Hashemi Goradel
1, Masoud Darabi
2*, karim Shamsasenjan
3, Mostafa Ejtehadifar
4, Sarah zahedi
41 Department of Medical Biotechnology, School of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Iran Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tabriz, Iran.
4 Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
Cell
therapy is a promising intervention for treating liver diseases and liver
failure. Different animal models of human liver cell therapy have been
developed in recent years. Rats and mice are the most commonly used liver
failure models. In fact, rodent models of hepatic failure have shown
significant improvement in liver function after cell infusion. With the advent
of stem-cell technologies, it is now possible to re-programme adult somatic
cells such as skin or hair-follicle cells from individual patients to stem-like
cells and differentiate them into liver cells. Such regenerative stem cells are
highly promising in the personalization of cell therapy. The present review
article will summarize current approaches to liver stem cell therapy with
rodent models. In addition, we discuss common cell tracking techniques and how
tracking data help to direct liver cell therapy research in animal models of
hepatic failure.