Adv Pharm Bull. 2017;7(3): 441-450.
doi: 10.15171/apb.2017.053
PMID: 29071227
PMCID: PMC5651066
Scopus ID: 85030107280
  Abstract View: 2131
  PDF Download: 1999

Research Article

Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design

Mahbubeh Hashemi 1, Vahid Ramezani 1*, Mohammad Seyedabadi 2, Ali Mohamad Ranjbar 3, Hossein Jafari 1, Mina Honarvar 1, Hamed Fanaei 4

1 Department of Pharmaceutics, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2 Department of Pharmacology, School of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
3 Department of pharmacognosy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
4 Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
*Corresponding Author: Email: vahidramezani@rocketmail.com


Purpose: Recurrent aphthous stomatitis (RAS) is the most common painful ulcerative disease of oral mucosa happening in ~20% of people. Aimed to develop Myrtus communis L. (Myrtle) containing oral patches, we applied box-behnken design to evaluate the effect of polymers such as Polyvinyl pyrrolidone (PVP), Gelatin, Methylcellulose (MC) and Pectin. Methods: The patches properties such as tensile strength, folding endurance, swelling index, thickness, mucoadhesive strength and the pattern of myrtle release were evaluated as dependent variables. Then, the model was adjusted according to the best fitted equation with box behnken design. Results: The results indicated that preparation of myrtle patch with hydrophilic polymers showed the disintegration time up to 24h and more. Using of polyvinyl pyrrolidone as a water soluble polymer and a pore-former polymer led to faster release of soluble materials from the patch to 29 (min-1). Also it decreases swelling index by increasing the patch disintegration. Gelatin and Pectin, with rigid matrix and water interaction properties, decreased the swelling ratio. Pectin increased the tensile strength, but gelatin produced an opposite effect. Thinner Myrtle patch (about 28µm) was obtained by formulation of methyl cellulose with equal ratio with polyvinyl pyrrolidone or gelatin. Conclusion: Altogether, the analysis showed that the optimal formulation was achieved with of 35.04 mg of Gelatin, 7.22 mg of Pectin, 7.20 mg of polyvinyl pyrrolidone, 50.52 mg of methyl cellulose and 20 mg of Myrtle extract.
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Submitted: 13 Feb 2017
Revision: 18 Aug 2017
Accepted: 23 Aug 2017
ePublished: 25 Sep 2017
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