Adv Pharm Bull. 2018;8(2): 217-223.
doi: 10.15171/apb.2018.026
PMID: 30023323
PMCID: PMC6046433
Scopus ID: 85048864523
  Abstract View: 2222
  PDF Download: 1349

Research Article

Porous Microparticles Containing Raloxifene Hydrochloride Tailored by Spray Freeze Drying for Solubility Enhancement

Seyyed Pouya Hadipour Moghaddam 1,2, Sajjad Farhat 3, Alireza Vatanara 3*

1 Department of Pharmaceutics and Pharmaceutical Chemistry, School of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA.
2 Utah Center for Nanomedicine, Nano Institute of Utah, University of Utah, Salt Lake City, UT 84112, USA.
3 Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
*Corresponding Author: Email: vatanara@sina.tums.ac.ir


Purpose: The goal of this study was to improve the solubility and dissolution behavior of Raloxifene Hydrochloride (RH) using Spray Freeze Drying (SFD) technique. Methods: For achieving this goal, series of samples containing RH with polyvinylpyrrolidone (PVP) or hydroxypropyl beta cyclodextrin (HPβCD) used as solubility enhancers were prepared and microparticles were formed via SFD. The resultant microparticles were physicochemically characterized. Morphology of the microparticles were observed using Scanning Electron Microscopy (SEM). High Performance Liquid Chromatography (HPLC) was used for analyzing the solubility and dissolution profile of the samples. Results: Fourier Transmission Infrared (FTIR) spectra showed that SFD processed compositions did not affect chemical structure of RH. SEM and Thermal Gravimetric Analysis (TGA) revealed that the fabricated spherical and highly porous microparticles were in amorphous state. SFD processed powders showed superior solubility and dissolution behavior; where, 80% of the drug was dissolved within 5 minutes. Conclusion: SFD method can be a promising alternative for enhancing the solubility of poorly water soluble compounds.
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Submitted: 26 Mar 2017
Revision: 12 Apr 2018
Accepted: 18 Apr 2018
ePublished: 19 Jun 2018
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