Adv Pharm Bull. 2015;5(2): 277-282.
doi: 10.15171/apb.2015.038
PMID: 26236668
PMCID: PMC4517075
Scopus ID: 84930394750
  Abstract View: 3037
  PDF Download: 3202

Original Research

Triamcinolone Acetonide Oromucoadhesive Paste for Treatment of Aphthous Stomatitis

Hamed Hamishehkar 1, Ali Nokhodchi 2, Saeed Ghanbarzadeh 3, Maryam Kouhsoltani 4*

1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Medway School of Pharmacy, Universities of Kent and Greenwich, Central Ave., Chatham Maritime, Kent ME4 4TB, United Kingdom.
3 Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Dental and Periodontal Research Center and Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.


Purpose: The aim of this study was to prepare the optimized oral paste formulation of Triamcinolone acetonide intended to be used in aphtous stomatitis. Methods: Plastibases were prepared using mineral oil and polyethylene (95:5). Oral paste formulations were prepared with different mixtures of three hydrocolloids solids, including gelatin, pectin and sodium carboxymethylcellulose, with different ratios, as well as Plastibase. Long-term and short-term stability of prepared formulations were studied in the case of color and consistency of pastes. Franz diffusion cell and dialysis membrane were employed for release study. Release data were fitted in the kinetic models to find out the mechanism of drug release. Results: Formulation containing 60% plastibase, 3.3% pectin, 6.6% gelatin and 30% carboxymethylcellulose showed desired durability of adhesion, spreadability and rheology property in healthy volunteers and was compared with reference formulation (Adcortyl®) in the case of release profile. Although, optimized formulation and Adcortyl followed the Higuchi and first order release kinetics respectively, optimized formulation showed similar release profile to reference formulation. Conclusion: Optimized oral paste formulation of Triamcinolone Acetonide showed similar characteristics with reference formulation and could be used as an effective drug delivery system for the treatment of recurrent aphthous stomatitis.
Keywords: Aphthous stomatitis, Triamcinolone acetonide, Plastibase, Oral paste
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Submitted: 16 Aug 2014
Revision: 10 Oct 2014
ePublished: 01 Jun 2015
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