Logo-apb
Adv Pharm Bull. 2013;3(2): 443-446.
doi: 10.5681/apb.2013.072
PMID: 24312875
PMCID: PMC3848239
Scopus ID: 84885753753
  Abstract View: 1104
  PDF Download: 834

Perspective

HLA-G Expression Pattern: Reliable Assessment for Pregnancy Outcome Prediction

Elnaz Mosaferi, Jafar Majidi, Mojdeh Mohammadian, Zohreh Babaloo, Amir Monfaredan, Behzad Baradaran*
*Corresponding Author: Email: behzad_im@yahoo.com

Abstract

Because mothers and fathers are more or less dissimilar at multiple HLA loci, mother considers her fetus as a semi-allograft. Mother's immune system may recognize paternal HLA as foreign antigen and may develop anti-paternal HLA antibodies and cytotoxic T lymphocyte. There are some mechanisms that modulate maternal immune responses during pregnancy, in order to make uterus an immune privileged site. This immunosuppression is believed to be mediated, at least partly, by HLA-G, non-classical class I human leukocyte antigen (HLA) molecule that is strongly expressed in cytotrophoblast and placenta. The major HLA-G function is its ability to inhibit T and B lymphocytes, NK cells and antigen-presenting cells (APC).Since HLA-G is expressed strongly at the maternofetal interface and has an essential role in immunosuppression, HLA-G polymorphism and altered expression of HLA-G seems to be associated with some complications of pregnancy, such as pre-eclampsia, recurrent misscariage and failure in IVF.This perspective discusses recent findings about HLA-G genetics, function, expression and polymorphism; and focus on HLA-G role in the etiology of recurrent miscarriage.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1105

Your browser does not support the canvas element.


PDF Download: 834

Your browser does not support the canvas element.

Submitted: 12 Apr 2013
Revision: 16 May 2013
ePublished: 20 Aug 2013
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)